Dorothy's daughter, Kate, comes to Miami with an announcement. She's engaged to a podiatrist named Dennis. Dorothy is thrilled but her happiness quickly turns to anger when she realizes that ex-husband, Stan, is going to be invited. After 38 years of marriage, Stan had left Dorothy for a woman half her age. Dorothy threatens to make a scene at the reception which places Rose and Blanche in the role of peacemaker.

A doctor Dorothy dates makes a pass at Blanche. But when Blanche tells Dorothy about it, Dorothy doesn't believe her. Dorothy accuses her of being a slut and when Blanche can't take no more she orders Dorothy to move out.

Dorothy's sister, Gloria, comes to Miami for a visit and asks Sophia to come live with her in California. Meanwhile, Blanche is furious when Rose is cast as Lady Macbeth, in a local play, and not her.

Dorothy is hesitant about having foot surgery just as she was scheduled to tap dance with Blanche and Rose at a dance recital.

One night after watching Psycho, the girls find it hard to sleep so they stay up and reminisce about how they all came to live with one another.

Dorothy's son, Michael, and Rose's daughter, Bridget, each come to Miami for a visit and each of them become a little too friendly for Dorothy and Rose's liking. Meanwhile, Blanche hurts her back in aerobics class.

The girls' dream vacation in the Caribbean turns out to be far from what was advertised in the brochure. While the girls are away, Sophia romances the gardener.

Blanche is convinced that her beauty is fading after attending her high school reunion and discovers many of classmates have had face lifts. Meanwhile, Rose is making a home movie for class she's taking.

The girls' search for a housekeeper ends when they hire Marguerite, a woman who appears to have mystical powers. However, when they fire her, a string of bizarre events convince the girls that Marguerite has placed a curse on them.

Dorothy is stunned to learn that Stan's tax problems are her tax problems since Stan is being audited for a number of years when they were still married. Meanwhile, Blanche and Rose take a Spanish class, each for different reasons.

Sophia got the girls a chance to appear on a hit game show Grab that Dough in California. At the hotel, they miss their reservations and they must sleep in the lobby...as a result, all their personal belongings are stolen. Sophia still has the tickets but once they arrive to the game, the girls fight and split into two separate competing teams.

As Sophia makes up her mind on whether or not to move in with her son, the girls continue to reminisce about the years they've shared together.

Feeling sorry for a lonely Sophia, Dorothy allows her to come along on a date with her and Dorothy's latest beau. However, pretty soon Sophia begins tagging along on every date which puts a rift in Dorothy's romantic plans.

Stan breaks the news that he's engaged to be married something Dorothy at first seems to accept. However, after Sophia falls ill, Stan comforts Dorothy which sparks old feelings in her and she contemplates trying to get back together with Stan.