Having not dated since her husband died, Rose reluctantly agrees to go on a blind date. This date turns into a serious relationship when she is invited on a cruise which would involve sharing a stateroom.

In a bowling competition, it's Dorothy and Blanche verses Rose and Sophia. If Sophia and Rose win, Dorothy will allow Sophia to go back to Sicily for a visit with an old beau and if Dorothy and Blanche win Sophia will give her a pair of antique earrings.

Rose has been dating Dr. Jonathan Newman and begins to think their relationship is leading to the alter. However she begins to have second thoughts especially since he's a midget.

Blanche's father, Big Daddy, comes to Miami for a visit, with an announcement, he's sold the family plantation and is setting out to become a country singer. Meanwhile, Sophia places a curse on a neighbor who refuses to remove his tree that fell over onto the lanai during a storm.

One night after watching Psycho, the girls find it hard to sleep so they stay up and reminisce about how they all came to live with one another.

The house is fumigated and the girls move into a Miami Beach hotel. Previously, Blanche had won three tickets to see the opening of Burt Reynolds new movie and passes to the party held afterwards where they could meet him. However, on the evening of the opening, the hotel is raided and, mistaken as prostitutes, Dorothy, Blanche and Rose are dragged off to jail.

The girls circulate a petition to save a 200 year old oak tree which is located on the property of the most hated woman in the neighborhood, Frieda Claxton, who wants the tree cut down.

The girls each plan to spend Christmas with their families but a series of strange occurrences lead them to spend Christmas together in Miami.

Dorothy, Blanche and Rose each vie for the attention of an actor in the local community theatre, who on the sly begins romancing each of them.

When the girls learn that a number of relatives are going to be visiting, they reminisce about times they've had to share a bed and strange places they've had to sleep, including a train station.

Sophia's sister, Angela arrives in Miami for a visit and decides to move there but while she's looking for an apartment Dorothy invites her to stay with the girls. This ticks off Sophia since she thinks that Angela is after everything that she has.

While preparing for a friend's birthday party, the girls recall past birthdays, including Rose's surprise birthday party for Dorothy, a surprise birthday party for Blanche and a memory of Sophia's birthday involving her late-husband Sal.

Sophia's latest get rich quick scheme prompts the girls to recall other various get rich quick schemes they've had over the years including, catering, a dance marathon and a memory of Sophia's from 1954.

Rose is shocked to learn that in her late-uncle's will he left her his ""Baby"". However she is quickly delighted to learn the ""baby"" is a pig but delighted is not a word to describe Dorothy, Blanche and Sophia, at least not until they learn that when Baby dies Rose gets a large sum of money.

Rose becomes concerned about nuclear war when girls in her cadet troop draw pictures of a bleak future. This prompts her to write letters to Gorbachev and Reagan. She's stunned when she gets a response and learns that Gorbechev would like to meet her.

Sophia's brother, Angelo, a priest, is coming to Miami for a visit and he doesn't know Dorothy and Stan are divorced. So in order to spare his feelings, Sophia convinces Dorothy and Stan to pretend to be married. Meanwhile, Rose and Blanche prepare to star in a play, The Sound of Music.

Sophia announces her intentions of moving out and in with her son Phil. This prompts the girls to reminisce about the good times and the bad times they've had together.

While waiting for phone calls from their children wishing them a happy Mother's day, the girls reminisce about past Mother's days.

Blanche's latest boyfriend is a charming Cuban whom sweeps Blanche off her feet but she's not the only one when Blanche discovers he's been dating Sophia behind her back. Meanwhile, Rose takes a course taught by Dorothy in order to get a high school diploma.

The death of a close friend, Esther Weinstock, brings Sophia face to face with Esther's husband a man whom she vowed never to speak to again due to things that happened in the past. However, when Dorothy prompts them to make up they get a little to close and wind up in bed together. Soon after, they announce their engagement, something that Dorothy is totally against. Meanwhile, Blanche and Rose begin a Elvis Presley fan club.

Sophia and Max come back from their honeymoon with no place to stay so Blanche, Dorothy and Rose put them up until they can find a place. Meanwhile, Sophia and Max decide to restart the old business Max had with Sophia's late husband, a pizza knish stand. However, Dorothy begins smoking again!

It's Valentine's Day, and the girls are all excited until each one of their dates cancel at the last minute. This leaves them to reminisce about Valentine's Day past.

Dorothy is in charge of a hospital charity show and things aren't going her way. She can't find any talent for the talent show and her emcee has just cancelled. Rose's solution for her problem makes things worse when the girls scour Miami in hopes of getting Bob Hope to perform in the show.

Blanche, Dorothy and Rose return home from a play to discover Sophia in the midst of selling the house. It's later discovered a for sale sign was accidentally placed on the front lawn but Blanche begins to consider it after seeing the amount that she's offered.