Rossa práve kvôli inej žene opustila manželka. Cíti sa zradený. Jeho sestra Monica a jeho kamaráti Chandler, Joey a Phoebe sa ho snažia utešiť v obľúbenej reštaurácii. V tom sa do podniku vrúti Monicina bývalá spolužiačka Rachel. Aj ona je nešťastná. Práve opustila snúbenca, utiekla zo svojej vlastnej svadby a nemá kam ísť. Obracia sa preto s prosbou o pomoc na Monicu. Tá ju vezme k sebe domov. Rachel sa konečne musí osamostatniť a postaviť sa na vlastné nohy. Začne pracovať v reštaurácii a pätica priateľov sa stáva jej novou rodinou. Ross mal Rachel rád už ako malý chlapec a dúfa, že by medzi nimi mohlo byť i niečo viac...

Rossa navštívi jeho bývalá manželka Carol a oznámi mu, že spolu čakajú dieťa. Ross je najprv poriadne prekvapený, ale potom chce byť pri všetkých veciach, ktoré s tehotenstvom súvisia. Spoločne s Carol a jej priateľkou Susan idú k lekárovi na kontrolu ultrazvukom a dohadujú sa, aké meno a priezvisko dieťa vlastne bude mať. Monica donúti Rossa k tomu, aby rodičom konečne oznámil, že je s Carol rozvedený. Rachel chce navštíviť bývalého snúbenca Barryho a vrátiť mu zásnubný prsteň.

Ross a Monica sú smutní, pretože ich babička náhle zomrela. Obaja ju idú naposledy navštíviť, keď ale prídu k jej lôžku, babička trochu nečakane na chvíľu "ožije" ...

Ross navštevuje s Carol a Susan kurz pre tehotné matky. Cíti sa však medzi ostatnými pármi trochu trápne. Keď raz Carol do kurzu nemôže prísť, Susan s Rossom sa dohodnú, že "výučbu" absolvujú bez nej. Po žrebovaní však musí tehotnú matku predstavovať Ross ...

Poranená Rachel a Monica idú na pohotovosť. Pri vypĺňaní formulára Rachel "zistí", že si neplatí poistenie, a musí využiť Monicinu poistku. Ošetrujú ju príťažliví lekári Mitchel a Rosen, s ktorými potom obe idú na večeru. Pretože si ale na príjme vymenili mená, snažia sa vydávať jedna za druhú. Veľmi im to však nejde, netrvá dlho a prerieknu sa ...

Keď priatelia prídu do pôrodnice, Carol so Susan tam ešte nie sú. Ross je krajne vynervovaný a nepríjemný k Susan. Phoebe chce trochu odľahčiť atmosféru spievaním pesničiek, jej repertoár však nie je príliš vhodný. Všetci sú nervózni, Monica najviac z toho, že ešte nemá dieťa. Chandler jej teda navrhuje, že ak sa do štyridsiatich rokov neožení, budú mať dieťa spolu. To však Monicu ešte viac rozčúli ...

Ross je dokonale zmätený. Nevie, či sa má rozísť s Juliou, alebo si začať milostný vzťah s Rachel. Chandler mu radí, aby si na svojom počítači urobil u oboch dievčat zoznam ich kladov a záporov a po porovnaní výsledkov sa môže rozhodnúť. Ross si zoznam pripraví s neobyčajnou dôkladnosťou, nakoniec sa ale zariadi podľa vlastných pocitov ...

When Janice asks the gang if any of them have ever slept together, the friends flash back to a time three years before.

Ross tries to prevent Rachel from learning his disturbing secret. She finds out anyway and they go back to her apartment to have a fight. The other four friends are trapped in Monica's bedroom, forced to listen in.

Phoebe is rushed to the hospital for the birth of her brother's triplets. While there, Joey winds up with severe sympathy pains that turn out to be kidney stones. Meanwhile, Rachel tries to set Monica up on a date with a male nurse.

Barry and Mindy's impending divorce prompts the gang to fantasize about what their lives might be like if they'd all taken different courses. Ross is still married to Carol, and Rachel is married to Barry, but fawning over famous soap star Joey Tribbiani. Monica is still fat and dating a doctor. Chandler is an aspiring writer and Phoebe is a Wall Street shark for Merrill Lynch.

The gang continue to fantasize about how different their lives could have been. Carol and Ross decide to have a threesome to spice up their marriage. Rachel goes to Joey's but is incredibly nervous about cheating and gets drunk. Meanwhile, Monica's dinner date falls through and Chandler tries to cheer her up but things take an unexpected turn.

The gang celebrate Monica and Chandler's engagement. Phoebe wants to be the musician at the wedding and comes up with a new song, while Joey tries to dress and act like a 19-year-old for an audition. Ross and Rachel briefly reunite and after Monica catches them kissing, she's convinced that Rachel is trying to steal her thunder.

So close to the wedding, Chandler suddenly realizes the overwhelming meaning of getting married and takes off without warning anyone. Meanwhile, Joey acts opposite a famous actor in a movie, but can't bring himself to tell him that he spits when he says his lines. Phoebe and Ross try to find Chandler before the wedding starts, while Rachel tries to hinder Monica, so that she doesn't find out the shocking news. On the day of the wedding Joey encounters a scheduling problem, while Phoebe and Rachel come across a surprising discovery.

The excitement of Monica and Chandler's wedding is diminished by the news that someone may be pregnant. Chandler's hopes of not embarrassing Monica on the dance floor are ruined by his slippery new shoes, and Ross' attempts to flirt with an attractive wedding guest.

Ross and Rachel go to the hospital to have their baby, but it's a long labor. They get stuck in a semi-private room, and many other couples come and go before Rachel is ready to deliver - the last couple being Janice and her new husband. Meanwhile, Chandler and Monica decide to start trying to have a baby, but can't find an empty hospital room where they wouldn't be disturbed. Also, Phoebe meets a handsome stranger and "recruits" Dr. Drake Ramoray to gather some personal information about him.

After Rachel gives birth to her little baby girl, she must confront relationship issues around her. So does Ross, who gets an engagement ring from his mother, while she urges him to propose to Rachel. The things, however, take an interesting turn.

Ross and Rachel hire a nanny for Emma named Sandy and things seem to be going great. However, Ross is uncomfortable having a male nanny. Meanwhile, Chandler becomes upset when Monica says that somebody from her new job is the funniest guy she's ever met. Also, after Phoebe and Mike decide to take their relationship to a new level and exchange apartment keys, Phoebe gets a surprise visit from her ex-boyfriend David.

Chandler gives David advice that culminates in David deciding to propose to Phoebe. However, Phoebe is still in love with Mike. Monica meddles and calls Mike, who shows up in Barbados and interrupts David's marriage proposal with one of his own. Phoebe chooses Mike, although she doesn't accept his proposal. Meanwhile, sparks fly between Ross and Charlie when they spend some time together rewriting his speech.

Charlie and Joey break up, and Rachel finally tells Joey about her crush on him. He decides nothing can happen because Ross is a good friend, but after he sees Ross and Charlie kissing, he heads back up to Rachel's room where the two kiss and shut the door. Meanwhile, Monica and Mike compete at a game of ping pong.

Joey is a celebrity contestant on "The $100,000 Pyramid," with its actual host, Donny Osmond. Phoebe's bachelorette party features a rather unexpected surprise when the stripper shows up. Chandler and Ross attend a college reunion and flash back to 1987 to reflect on a pact they made when they were in college.

When Rachel makes a startling announcement, Ross secretly schemes to get her former job back for her. Joey is so flustered by all of the upheaval in his friends' lives that Phoebe prevents him from learning about the sudden death of his agent. Monica and Chandler check out the house for sale next door to their new home--and make a stunning discovery.

Ross and Phoebe chase Rachel to the airport, but end up at the wrong one. Chandler and Monica finish packing for their move to the suburbs, and Joey loses Chick Jr. and Duck Jr. in the foosball table.

The series finale finds Rachel, Monica, Phoebe, Joey, Chandler and Ross embarking on the next chapters in their lives. The six of them have been there for one another through all the ups and downs of becoming adults. Now it's their last day together, and it's one of momentous events and last-minute surprises. Even as the friends make major decisions, they share a bond that will last forever.