In three parodies of MacGyver, the titular hero (Forte) demands odd objects of his disgusted sidekicks (Jeremy Piven, Rudolph) in his attempts to stop catastrophic events that are mere seconds away. The episodes invariably end with his failure to stop the event.

In three more segments, the titular hero (Forte), after 15 years of sobriety, begins drinking just as his sidekicks (Molly Shannon, Rudolph) need his bomb-defusing skills most. MacGruber's behavior evolves into a parody of David Hasselhoff's hangover video.

In three more segments, the titular hero (Forte) becomes obsessed with his recent plastic surgeries just as his sidekicks (Seth Rogen, Rudolph) need his bomb-defusing skills most.

MacGruber feels insecure when his assistant says that he cannot do his job when he and Vicky need his bomb-defusing skills the most.

MacGruber and his son Merrill team up together. However, in the process of escaping, Merrill inadvertently confesses that he's gay leaving MacGruber to make him straight again by reciting Bible verses and forcing him to kiss Vicky.

MacGruber discovers he lost all his money in the stock market and seeks desperate ways for cash just as his sidekicks need his bomb-defusing skills most.

MacGruber is joined by MacGyver, who reveals that he's MacGruber's long-lost father, who left MacGruber's mother for a stripper.

When MacGruber gets an African-American sidekick, he inadvertently reveals that he is a racist.

MacGruber works with his grandma, who embarrasses him by telling Vicki stories about his past.