Peter Parker's nerdy high-school friend, Max, is hazed in a deadly fraternity prank that turns him into Electro, a high-voltage villain that threatens the campus. Only Spider-Man can stop him from exacting his revenge on the students.

The master martial artist and swordswoman, Shikata, is sent to capture Spider-Man for a wealthy man's collection of rare animals; and Shikata determines that Spider-Man is too noble a foe to simply capture, so they must fight to the death.

Peter's professor, Doc Connors, injects himself with reptilian DNA, which slowly changes him into the angry, vengeful Lizard; and since the serum affects Doc Connors' brain, Spider-Man must stop his beloved professor as he begins seeking revenge on those who have harmed him, including Harry.

Spider-Man is out to catch Talon, a female thief who is responsible for high-risk robberies in the city. Things get complicated when Spidey finds out that Talon is his best friend Harry's new girlfriend.

A team of three ex-KGB agents called Pterodax take people hostage, including Peter and Indy, his new crush. They want Spider-Man, so Peter must figure out a way to appease Pterodax without revealing his alter ego.

Peter Parker's lab partner Christina reads his mind with her new invention: an ESP crown. The crown malfunctions, jolting her own brain with electricity and altering her reality. No longer able to distinguish fantasy from reality, Christina attempts to kill M.J. in order to limit the competition for Spider-Man's eternal affection.

Electro returns from his seeming death and tries to make Sally, a girl he has a crush on, become an electrical being just like him.

Peter covers a press conference and inadvertently videotapes incriminating evidence against Silver Sable, an Eastern European assassin for hire. Now she will stop at nothing — including killing Mary Jane, Harry, and Indy — to get the tape back.

Spider-Man is duped by the infamous Kingpin into stealing the TX-1 super-chip, designed to decrypt the confidential satellite transmissions that drive the world's financial markets. Now he must find a way to get it back.

Spider-Man battles Turbo Jet, a modern-day Robin Hood armed with a homemade propulsion system, who steals from the wealthy and gives to the poor. Spidey's life gets even harder as the public rallies around Turbo Jet – and against Spider-Man.

Dr. Zellner tests his "smart drug" on Peter Parker foe Flash Thompson, and Flash immediately displays dramatic spikes in intellect. However, along with the IQ boost comes a potentially fatal side effect. With only minutes to find an antidote, Zellner takes Flash's suggestion that he experiment on an already intelligent candidate: Peter Parker.

Los mellizos Gaines, un hermano y hermana con habilidades telepáticas, escapan de un convoy armado, pero Spider-Man los arresta después de superar sus oleadas mentales con su voluntad super humana. Después, justo cuando Spider-Man le revela a Mary Jane que en realidad es Peter Parker, Kraven el Cazador lo confronta.

Spider-Man descubre que fueron los gemelos Gaines quienes lo engañaron haciéndole creer que Mary Jane había muerto en las manos de Kraven. El acorrala a los mellizos – pero todo da un giro inesperado cuando otra vez engañan a Spider-Man. Esta vez forzándolo a que lastime a Indy. Podrá la culpa hacer que Peter cuelgue su traje de Spider-Man ¿para siempre?