On a world where a biological weapon wiped out most of the male population, Quinn, Rembrandt and Arturo become objects of desire and are imprisoned by the government to be breeders. As they try to escape and regroup with Wade, they find there are others out to capture them.

A lightning bolt strikes the vortex during a slide, damaging the timer and trapping Quinn on the astral plane. Now the Sliders are stranded on a world with 1950s technology and Quinn can not be seen by the others. He tries to get the help from the only one who can see or hear him, a girl that has a history of hearing voices.

Wade witnesses a murder just before the slide, but as the Sliders land on the next world, the same murder is about to occur. This time, Wade intervenes and this gets the Sliders involved with a disgraced federal judge and a United States under martial law.

The Sliders have come to the most unexpected world of all... home. While Rembrandt and Wade use their sliding adventures to kickstart their careers, Arturo steals the timer and claims sliding as his invention. However, Quinn remains convinced they are not home.

The Sliders arrive on a world where the young are in charge and Wade and Quinn's doubles were married corporate executives. Quinn winds up posing as his dead double and finds questions in his death. Meanwhile, Arturo and Rembrandt find themselves in trouble with the law and face jail time.

On a world quickly running out of natural resources, Rembrandt meets his number one fan but finds her to be a little too friendly. Meanwhile, Quinn and the others meet Logan, a scientist at Prototronics that's trying to develop sliding. However, they learn her plans for sliding are far from noble.

The Sliders arrive on a world where electric tornadoes have almost completely wiped out the population. They find a secluded village somehow protected from the tornadoes and a dictator that may prevent the team from ever sliding again.

The Sliders land on a world with little water and come to the aid of a mysterious young woman whose gift to find water is being exploited by a group of thugs.

On a world where the American government is a monarchy, Rembrandt is mistaken for his double and discovers that he is about to be a father of royalty. The only problem is, on this world, it's the men who give birth to children.

On an over-worked world with an uptight population, Arturo is thought to be a fracture and is sent to a fantasy camp for a form of relaxation. When the others find him, they see he has been brainwashed into thinking he is a great detective on the trail of a Jack the Ripper-like murderer.

The Sliders arrive on a world where a strange bacteria transformed the inhabitants into flesh-eating zombies. When Quinn is bitten, he begins to turn into one of them.

Wade and Rembrandt recall their slide to a world plagued by earthquakes and populated by primitive people. Wade falls into a deep chasm and Quinn goes to rescue her, while Rembrandt learns of Arturo's illness.

Wade falls under the spell of a rock band's charismatic lead singer, who is really a vampire and looking to use Wade to get the timer. Meanwhile, the others try to track down Rickman.