The Sliders land on a world with little water and come to the aid of a mysterious young woman whose gift to find water is being exploited by a group of thugs.

The Sliders arrive in a small community, where the citizens are all young and fearful of outsiders. They don't expect much trouble, until they uncover a deadly secret.

While on vacation, Quinn and Rembrandt get mixed up in an illegal snake deal and find themselves stuck in the middle of no where surrounded by deadly snakes. Meanwhile, Wade and Maggie get involved with a shady man in their search for the others.

The Sliders track Rickman to a world where a mad scientist has been experimenting with genetic testing and has created a race of human hybrids.