After separating from Ryan and Henry the dog, the Sliders make a rough landing that reopens Quinn's bullet wound. On this world of mysticism and superstition, a witch doctor heals Quinn and has brains on the mind when they can't pay the bill. On the run from bounty hunters, the Sliders only hope is the mysterious Sorcerer, a man who could possibly get them home.

The Sliders arrive on a world where the young are in charge and Wade and Quinn's doubles were married corporate executives. Quinn winds up posing as his dead double and finds questions in his death. Meanwhile, Arturo and Rembrandt find themselves in trouble with the law and face jail time.

The Sliders land in the middle of a strange invasion and Quinn uses the timer to bring down one of the ships. Before barely escaping, the Sliders learn these new villains can slide at will and are soon captured on the next world. They learn their captors are the Kromaggs and are intent on conquering every parallel world.

The Sliders find themselves running into the same people on each new world, one of them being Quinn's former love, Daelin. After encounters on worlds where the Spanish rule America and Daelin is an abused wife, the Sliders arrive on a world where time moves backwards and they are accused of Daelin's murder. Quinn wants to save her, but it could have disastrous results.

On a world quickly running out of natural resources, Rembrandt meets his number one fan but finds her to be a little too friendly. Meanwhile, Quinn and the others meet Logan, a scientist at Prototronics that's trying to develop sliding. However, they learn her plans for sliding are far from noble.

On a world where the American government is a monarchy, Rembrandt is mistaken for his double and discovers that he is about to be a father of royalty. The only problem is, on this world, it's the men who give birth to children.

On a world where the legal system is in the form of televised game shows, Quinn is arrested, tried and sentenced to death for the crimes of his double.

On a world where people are enticed by consumerism and giant malls in the sky, the Sliders get jobs as mall employees to find the mother of an abandoned child. Arturo is a reluctant Santa, Rembrandt and Wade his elves while Quinn gets an administrative job. Meanwhile, Wade faces some strong emotions when she meets her sister and father.

The Sliders' chase for Rickman takes them back to the world they helped colonize, the New World. Only they find that the colonists are being hunted by a hungry Tyrannosaurus Rex.

The Sliders arrive in a barren wasteland, where the timer is inoperable. Worse yet, they find themselves forced to take part in a never ending battle between Kromaggs and soldiers from Quinn's home world, who are guarding a mysterious bunker.

Just before sliding out and escaping a small army, Mallory is shot with a laser beam and paralyzed. His only chance of walking again lies in a group of spiritual healers, but their cure could be much worse than being paralyzed.