When Custer and Crazy Horse are both captured by Blackfeet who are hostile to both whites and the Sioux, the two enemies must work together in order to escape and stay alive.

After a period of leave, Custer takes a stagecoach back to Fort Hays that is menaced by both outlaws and hostile Native Americans.

Custer is given the task of stopping a band of Irish fanatics who are plotting to invade Canada.

Custer enlists the aid of some Kiowas to help him discover the parties responsible for a series of wagon train raids.