Outside a bizarre, gruesome crime scene, Los Angeles beat cop Matt Parkman is the only one who can hear the cries of a missing little girl. Claire almost reveals her secret ability to the entire school after learning that her injury attempt tape has disappeared. Thinking she's going crazy, Niki loses another block of time after waking to find some brutally murdered thugs in her garage, only to be confronted by Social Services about son Micah. While office drone Hiro investigates New York, Nathan confronts Peter following his plunge off a building.

As the "Heroes" continue to test their newfound extraordinary abilities, Claire tries to maintain a normal social life when a romance with the football quarterback takes a tragic turn. While Hiro convinces his friend that they are destined to travel to America to save the world, a frightened Niki follows instructions from a mysterious, unknown source that directs her to the middle of the desert.

Meanwhile, Nathan uses Peter's accident to propel his political campaign. The elusive Sylar is being hunted by both Matt and the FBI, as well as Suresh, whose father's journal leads to potential clues.

Hiro and Ando's determination is put to the test. Nathan wants to win the election and he's taking drastic measures to ensure that he will. This episode will feature Sylar, his home life, and where he came from. Jessica and D.L. discover some of the stuff that Linderman wants from them and Micah. Also there is a new hero who is supposed to be holding the key to stopping Sylar.

Poised to become a member of Congress and maybe more, Nathan considers the cost to those he loves, along with his mother's advice and Linderman's prophecy. As he prepares to face Sylar to the death, Hiro learns of his lineage from his father. While various "heroes" fatefully arrive in New York City, Peter and Claire attempt to leave the city before the foretold explosion. H.R.G.

Can Sylar be stopped? Will Linderman's vision live on with Nathan? What will it take for Peter to save the world, what sacrifices will be made? With all the horrible predictions unfolding before them the heroes face moments of pain and peril in Kirby Plaza.

Four months after the events of the showdown between Sylar and Peter, new Heroes emerge. These include brother and sister Alejandro and Maya. Hiro remains in the past, but what will come of this? Someone dies and someone isn't dead. Claire and her father and the rest of their family get a new life.

Peter falls in with Irish gangsters who know about his past. Hiro works to contain the damage caused by his journey into the past. Kensei's power will be revealed. Suresh locates and cures the Haitian. Matt investigates the murder of Mr. Nakamura. West comes to know of Claire's powers. Maya and Alejandro enter Mexico and find their powers more of a hindrance than a help.

Suresh finds an undiscovered Isaac Mendez painting that shows someone's death; Maya frees Alejandro from a Mexican jail; in the past Hiro discovers something new about Kensei; and Niki and Micah leave Las Vegas to get away from their past. Claire and West take a little trip.

Monica starts to exhibit new abilities while working with Micah, Nana, and Damon. Nana is the grandmother of Micah, Monica, and Damon. They all currently reside in New Orleans. Matt asks Molly to locate the man in her dreams. He may be the newest threat to the Heroes. Maya and Alejandro continue their trek to the U.S. Both Claire and her father are suspicious of one another. Angela reveals a lot of her secrets.

A woman named Elle is searching for Peter. Ando looks for Hiro in the past. Matt looks for the man in Molly's dreams. HRG takes another step in hopes of protecting his family and himself.

Peter goes on a search. West convinces Claire to stand up to someone. Hiro struggles with his feelings for Yaeko. Suresh has more problems with the Company. HRG tries to locate more of Isaac's paintings. Alejandro doesn't trust Sylar.

Peter and Caitlin learn about the endstage effects of the Heroes virus. Many of the Heroes work together to fight the Nightmare Man. West is shocked to the identity of Claire's father. Hiro and Kensei's journey comes to an end.

Mr. Bennet prepares to move his family when he thinks the Company has found them, but Claire doesn't like the idea. Hiro returns to the present and upon discovering his father's death, travels back in time to stop it. Meanwhile, Matt works to master his new mental abilities.

Peter travels to Primatech in Texas to destroy the virus, but not everything is what it seems. Hiro continues the pursuit of his father's killer, while Matt pursues the last Company member in the photo. Nikki is reunited with Micah but has bad news, while Maya has to choose to remain with Alejandro, or go with Sylar.

In Texas, Peter faces off against former friends due to Adam’s misleading story about the Shanti virus. Micah enlists the help of his mother to rescue Monica. Maya is shocked when she learns the truth about her new friend Sylar. Elle tries to make her father proud.

Peter travels to the future and adopts a dangerous ability in order to try to save the world. Meanwhile, Mohinder struggles with his continuing evolution from the formula, and Hiro and Ando re-unite with an old enemy.