Picking up where the finale left off, Sam and Dean must deal with the Darkness that has been unleashed. Castiel deals with the effects of Rowena’s spell and recalls his brutal battle with Crowley.

While Rowena tries to consolidate her power to protect herself from the Winchesters, Sam and Dean search for a missing baby connected to the Darkness. Meanwhile, Castiel struggles to heal and Crowley tries to find a way to use the Darkness for his own personal gain.

Amara unleashes her power on the local townspeople as she issues a shocking challenge. Dean tries to better understand the hold Amara has on him, while Sam and Crowley come up with a plan that could have disastrous consequences.

Now that he has Sam in the cage with him, Lucifer offers Sam a way out but it comes with a steep price. Dean and Castiel look into the angel smiting that could have killed Amara.

Hoping to find a weapon powerful enough to defeat Amara, Dean convinces “Castiel,” who is still Lucifer, to send him back in time to 1944 to the fated submarine mission that sunk the Hand of God. Meanwhile, continuing his charade with Sam while they wait for Dean’s return, Lucifer plans his next move.

Lucifer takes a trip home and tries to assert himself into Heaven. Crowley tells Sam and Dean he has a way to take down Amara.

Amara unleashes a dark fog on a small town, causing everyone to go mad. Dean and Sam realize this is a stronger version of the original black vein virus Amara previously unleashed. They team up with the sheriff to protect the town but their old remedy no longer works. Meanwhile, Chuck returns with an interesting proposal.

Amara shows Dean how she’s torturing Lucifer. Worried for Castiel, Dean and Sam come up with a plan to rescue him from Amara’s clutches.

Sam and Dean face their biggest challenge yet. Rowena makes her move.

God comes to a decision about Amara that has direct repercussions for Sam and Dean.

Sam, Dean and Castiel call on Rowena to help keep the evil souls at bay and get an unexpected assist from Ketch.

Castiel and Jack work a case involving members of a local church. Meanwhile, Sam and Dean go off in search of Amara.

Dean hits the road with Jack who needs to complete a final ritual in the quest to beat Chuck. A difference of opinion leaves Sam and Castiel behind looking for answers to questions of their own.