Two brothers, Sam and Dean Winchester, witness their mother's paranormal death as children and grow up trained to fight by a distraught father who wants nothing more then to hunt down the thing that killed his wife. Sam escapes to college to start a new, normal life, but gets pulled back in after Dean shows up on his doorstep to tell him their father is missing.

Following clues from an eerie phone message from him, the boys travel to a small town and encounter a vengeful spirit called the "Woman in White" who then starts to haunt Sam.

Sam and Dean follow the coordinates left in their father's journal and land in the middle of the woods where they investigate the disappearance of several campers. The two brothers soon learn they are dealing with a Wendigo, a creature made famous in Native America legends. A Wendigo is a former human whose cannibalism has transformed him into a creature with superhuman strength and speed that feasts on human flesh.

Sam and Dean investigate a series of mysterious drownings written off as suicides. They discover the spirit is an angry little boy with the power to travel through water who is taking revenge on certain town inhabitants for a dark secret buried long ago. Dean forms a bond with a young boy who seems to have the power of premonition.

On TransNational flight 2485, a man possessed by the spirit of the Phantom Traveler causes the plane to crash, leaving only five survivors left alive. Sam and Dean must exorcise the angry spirit before it attacks the survivors. The brothers realize the only way to do that is to take the battle to the skies.

In suburban Nebraska, a group of partying high school teens jokingly dare their friend Charlie to look into the mirror and repeat "Bloody Mary, Bloody Mary, Bloody Mary," not knowing this will unleash a series of mysterious murders. Sam and Dean realize that Bloody Mary has the power to travel through all reflective surfaces when she is hunting a victim. Worried that teens are accidentally summoning Bloody Mary, Sam and Dean race to destroy the violent spirit before she can kill again.

Sam and Dean come to the aid of Sam's old college buddy after he is accused of a murder he swears he didn't commit. The brothers discover a shapeshifter is adopting the likenesses of others and murdering people. The brothers' race to stop the shapeshifter takes a terrifying turn when he shifts into the likeness of Dean.

The infamous "Hook Man," a vengeful spirit who kills his victims with a shiny hook that serves as his hand, terrorizes a small college town in Iowa. Sam and Dean learn that all the victims are connected to the daughter of a local minister and race to find and destroy the Hook Man's bones before he comes for them.

After a construction worker is killed by insects burrowing into his brain, Sam and Dean investigate the town's history and find that the new housing development is being built on sacred Indian land. The Indians put a curse on the land after their reservation had been ravished and destroyed. Sam and Dean must find a way to survive and kill the deadly swarm of bees, locusts, spiders and beetles.

Sam is haunted by a vision of a woman trapped in his childhood house and convinces a reluctant Dean that they need to go home. Upon arrival, they meet the woman in Sam's premonition and she reveals that the house is haunted. Looking into their personal history, the brothers discover their father had visited a psychic after their mother's death and they turn to the same woman for answers of their own. Together they discover a malevolent poltergeist has inhabited the house and set out to exorcise it, but are blindsided when another unseen spirit steps in.

Sam and Dean investigate an abandoned sanitarium and discover that when the hospital was open, the patients held a revolt against the cruel and unusual punishments inflicted by the head doctor. While the brothers search the premises for four lost college students, the tortured spirits cause them to go insane, turning Dean against Sam.

Sam and Dean finally make contact with their father, but he tells them to stop looking for him and sends them on another ghost-hunting job. Frustrated with their father's evasiveness, Sam sets out alone to find him while Dean stays back to obey his father. Dean investigates a small town in Indiana where couples have gone missing the same day each year and discovers the farmers are sacrificing them to a Pagan God who takes the form of a scarecrow.

While battling a demon, Dean is electrocuted, resulting in permanent damage to his heart and leaving him with only a couple of months to live. A despondent Sam searches desperately for a way to save his brother and believes he may have found an answer through a preacher who claims to heal the incurable. However, Dean and Sam discover that the preacher is getting help from the Grim Reaper who is trading one life for another he feels is less worthy.

Dean is contacted by his first love Cassie, an African-America girl, who asks him to come to Mississippi to investigate a string of racially motivated murders. Each murder is linked to a mysterious truck that seems to have no driver and leave no tracks. Sam is stunned to see this new side of his brother as Dean struggles to come to grips with the residual feelings he has for Cassie.

Sam has a premonition in which a man is killed, but the murder is made to look like a suicide. Sam convinces Dean that they must investigate the case, but the two are puzzled when they fail to find anything that indicates that the death was supernatural in nature. That is, until they find out that Max, the reclusive son of the first victim, has been using his recently acquired power of telekinesis to kill the family members that once abused him. Sam also discovers Max's mother was killed by the same fiery demon that took his own mom.

Sam and Dean head to Minnesota where a young boy witnesses a man vanish into thin air. Upon searching for clues, Sam is abducted by what he assumes is a supernatural being, and Dean is left to search frantically for his brother. However, both are stunned when they realize the kidnappers are human, and using the captives as human prey for a twisted hunting expedition.

Sam has a reunion with a girl he once met, Meg, but it turns out that she is using the brothers to lure their father John to his doom.

Sam and Dean investigate the case of a maniacal ghost inhabiting a long abandoned Texas farmhouse known as "Hell House." They believe the ghost is the spirit of a deceased Depression-era farmer who killed his family, but they soon realize it is something far more powerful.

Sam and Dean battle a Shtriga, a witch that sneaks into childrens' bedrooms and sucks the lives out of them. Dean must relive his childhood when he remembers that he encountered the Shtriga years ago.

The Winchesters must deal with a dangerous spirit bound to an old family portrait that brings misfortune and death to anyone who buys it.

To obtain a mystic gun capable of destroying the demon that killed their mother, Sam and Dean must team up with their father John and face off against vampires.

John has realized where the demon will strike next and the Winchesters head there to stop the next killing. But Meg begins killing John's friends and demands the Colt or she'll keep going until everyone John knows is dead.

When Meg boasts that John is her prisoner, the boys visit a friend of their father's to get information about demonic possessions and ways to trap a demon. It turns out Meg is not what she appears.

Sam and Dean are left to pick up the pieces after the loss of their mother, the demise of Crowley and the heartbreaking death of Castiel. The birth of Jack leaves the Winchester brothers with differing opinions on how to deal with a Nephilim. After being dragged into the breach, Mary must learn to survive Lucifer and an apocalyptic world.

Sam and Dean begin to explore what Jack is capable of doing with his powers. An unexpected visit from Donatello alerts the boys to the fact that Jack will need more protection than the Winchesters can provide. There is a new Prince of Hell in town, Asmodeus, and with Lucifer out of the picture, he sets his sights set on Jack.

When her friend is murdered by a wraith with a taste for psychics, Missouri enlists the help of Dean and Jody to protect her granddaughter, Patience, who has no idea she shares her grandmother’s trait and could be next on the wraith’s hit list. Meanwhile, Sam continues to work with Jack on learning how to control his powers.

When multiple patients of grief counselor Mia Vallens turn up dead, Dean, Sam and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.

While working on a case involving the ghost of a demented doctor, Sam and Dean get assistance from an unexpected source – Billie. Castiel finds his way back to the Winchesters.

Castiel is reunited with Jack and together with Sam and Dean, they head to a sleepy old western town to investigate a murder. Dean gets to live out his boyhood fantasy when he comes face to face with a famous, gun-slinging outlaw.

As Sam and Dean continue their search for Jack, with Asmodeus hot on their trail, they stumble across a familiar foe. Meanwhile, Lucifer manages to escape Michael’s grasp and finds himself an unlikely and mostly unwilling ally.

Sam and Dean join the crew of a heist on behalf of a Crossroads Demon who has offered them a spell that can track Nephilim.

Jack, desperate to prove to Sam and Dean that he is good and that he can control his powers, enlists the help of a dreamcatcher named Kaia to help him find Mary Winchester and save her from the alternate universe. However, when plans go awry, the Winchester brothers are the ones who need saving.

When Sam and Dean go missing, Jody Mills calls Claire Novak, the rebellious rogue hunter, and tells her it is time to come home – they need to find the Winchesters. Claire returns and reunites with Alex Jones, who has stayed behind with Jody and tries to balance a “normal” life with being a part time hunter. While Jody is happy to have Claire home again, she’s plagued by Patience’s disturbing vision involving her adopted daughter. Claire and Alex search for Kaia Nieves, the dreamcatcher responsible for opening the rift that Sam and Dean went through, as she holds the key to their whereabouts. Jody calls her friend, Donna Hanscum, to round out the team and the women head off on the most important hunt of their lives.

Donna calls Sam and Dean for help after her niece, Wendy, goes missing. The three hunters discover Wendy was kidnapped by a man who sells human parts to monsters in a grotesque online auction and race to save her before it is too late.

Dean falls victim to a couple of witches, sisters Jamie and Jennie Plum, who manage to steal a powerful book of spells from the Winchester brothers. When Sam and Dean go after the book, they get help from a powerful and surprising ally when Rowena, back from the dead, intervenes to assist them.

Sam, Dean and Castiel search for Lucifer who, meanwhile, strikes an unlikely deal with a local faith healer named Sister Jo. Asmodeus inches closer to finding Jack.

Jack and Mary manage to escape Michael’s clutches and end up finding an ally in “apocalyptic world” Bobby Singer. Meanwhile, Sam, Dean and Castiel continue to search for a way to open a breach, not realizing that one of their own may be working against them and costing them precious time.

Sam and Dean are close to collecting everything they need to open a rift into the Apocalyptic World and possibly rescuing Mary and Jack. The one missing ingredient leads the Winchesters to a black market for religious relics where everything is not always as it seems.

Sam, Dean and Castiel are transported into the animated world of Scooby Doo where they join forces with the Scooby gang to solve a ghostly mystery.

Sam and Dean continue to collect the pieces necessary to open a rift to the other world in order to save their family. Their latest quest leads them to a Men of Letters bunker from the 1920s and a hungry God from another dimension. Meanwhile, Ketch makes a shocking decision about Gabriel after an unruly encounter with Asmodeus.

Lucifer rules over heaven but things aren’t going exactly as planned, exasperating his first lady, Jo. Sam and Castiel are perplexed by the return of Gabriel. Meanwhile, Dean gets one step closer to finding Mary and Jack.

Sam and Dean must stop Rowena, who is on a deadly mission. Meanwhile, Castiel looks to heaven to recruit angels for an impending invasion but is shocked by not only what he finds, but who.

Gabriel is back and drags Sam and Dean into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's inflating confidence leads to reckless decisions that could put others in harm's way.

Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena’s encounter with Lucifer may alter the outcome of the journey for one of our heroes.

Sam and Dean devise a plan that will save innocent lives. Meanwhile, Jack continues to wrestle with the consequences of his decisions.

Our heroes, Sam and Dean Winchester, continue to be tested in the battle between good and evil, but one impulsive decision could alter the lives of one the brothers forever.