After the events at the hospital, the brothers have no idea where the demon that killed their mother is hiding. While biding their time trying to come up with an idea, they investigate murders committed by a killer clown.

Sam and Dean encounter a vampire hunter whose obsession may get them all killed.

Sam and Dean investigate the slayings of blonde women and find that the ghost of the first known serial killer in US history is responsible. Jo disobeys Ellen's wishes and follows them along, and is captured by the ghost.

Sam meets a woman who shares his ability to have visions, and she warns him that she has seen the future... where he dies in an explosion.

After the fight between Jake and Sam, Dean has to make the ultimate sacrifice for his brother. Meanwhile the Yellow-Eyed Demon has his new servant and plans to unleash the hordes of Hell.

Hunter Rufus Turner calls in Bobby, Sam, and Dean to deal with a demon infestation in his town, but they soon discover the truth is much more horrifying. Meanwhile, Castiel goes to seek the only entity that can defeat Lucifer.

Sam, Dean and Castiel track down the Colt and head off to find Lucifer to send him back to Hell. It’s a hunters’ reunion when the crew joins forces with Bobby, Ellen and Jo for what could be their last night on Earth.

After Balthazar changes history and keeps the Titanic from sinking, Fate intervenes and begins killing those that would have died on the ship. Castiel tells Sam and Dean that Fate is very upset with the two of them and the only way they can stay alive is to kill her.