Dean helps Jenna, the deputy he met after the Darkness fell, get back home safely and then sets off to help Sam deal with a town infected by a mysterious and deadly gas. However, when Jenna falls into dangerous hands, she calls Dean for help and Sam tells him to go back to her. Unfortunately for Sam, he isn't able to handle the townspeople turned monsters as easily as he thought.

Now that he has Sam in the cage with him, Lucifer offers Sam a way out but it comes with a steep price. Dean and Castiel look into the angel smiting that could have killed Amara.

Sam and Dean battle a pair of werewolves who have captured two victims. Just as the brothers are about to win, one of the werewolves shoots Sam. Dean gets his brother and the victims out of the house but learns a pack of werewolves are hot on their tail, hoping to kill them all.

God comes to a decision about Amara that has direct repercussions for Sam and Dean.

When hunters gather together to celebrate the life and tragic death of one of their own, Sam, Dean, and Mary must take action when a demon starts picking off hunters one by one.

After being arrested for the attempted assassination of the President of The United States, Sam and Dean must find a way out of an underground, government-run, detention facility in the middle of nowhere. Determined to find her sons, Mary and Castiel seek assistance from an unlikely source.

While working on a case involving the ghost of a demented doctor, Sam and Dean get assistance from an unexpected source – Billie. Castiel finds his way back to the Winchesters.

Sam and Dean must stop Rowena, who is on a deadly mission. Meanwhile, Castiel looks to heaven to recruit angels for an impending invasion but is shocked by not only what he finds, but who.

Michael has re-taken control of Dean as his army of monsters continues to move in on our heroes. Sam devises a plan to try and reach Dean and stop Michael before anyone else has to die.

Sam, Dean and Castiel are thrown into an epic battle. Meanwhile, Jack becomes disenchanted with all the lies, and an old friend from the past shows up.

Sam and Eileen are faced with the brutal truth. Meanwhile Dean and Cass work together in the hopes of getting a step ahead of Chuck.