In this Christmas-themed episode, Sam and Dean follow the trail of an "anti-Santa" that abducts its victims by using their chimneys. Dean tries to get Sam to celebrate Christmas like they used to but Sam doesn't want to accept that it could be the last one they'll spend together.

Fast times at Truman High. Murder brings Sam and Dean back to one of their old high schools, where they investigate possible demonic possession and take a few trips down memory lane.

Dean and Bobby have something frightening locked in Bobby's panic room: Sam, contaminated by demon blood. But as the apocalypse draws nearer, Bobby wants to free Sam to battle on their side.

Ambushed by angry hunters, Sam and Dean are shot and killed and sent to Heaven. Castiel warns Dean that Zachariah is looking for them in Heaven so they need to lay low while searching for an angel named Joshua who can help them since he talks directly to God. While searching for Joshua, the brothers run into some old friends and family members.

Dean is furious after Sam disappears to follow a lead on a case with clues that are identical to a case Sam solved as a kid. The demon turns out to be Amy, who has been killing low-life thugs and taking their brains for dinner - the same demon Sam found as a kid.

Now that he has Sam in the cage with him, Lucifer offers Sam a way out but it comes with a steep price. Dean and Castiel look into the angel smiting that could have killed Amara.