Megan Donner returns to the CSI unit in time to work on a jet crash in the Everglades. While searching for survivors, they inexplicably discover a female victim found five miles from the crash site. When the only survivor says the woman opened the plane's hatch in order to commit suicide, Horatio is suspicious. The team must now recreate what happened on that fatal flight, especially when the pieces don't quite fit together.

A serial bomber is on the loose. Will the team with the help from Caine's old bomb squad mentor be able to work out the puzzle and find the bomber?

An arm in a shark's gullet and a girl who was shot at sea lead the team to a smuggler who was running Cuban refugees and cocaine in a foundering ship.