Megan Donner returns to the CSI unit in time to work on a jet crash in the Everglades. While searching for survivors, they inexplicably discover a female victim found five miles from the crash site. When the only survivor says the woman opened the plane's hatch in order to commit suicide, Horatio is suspicious. The team must now recreate what happened on that fatal flight, especially when the pieces don't quite fit together.

A serial bomber is on the loose. Will the team with the help from Caine's old bomb squad mentor be able to work out the puzzle and find the bomber?

An arm in a shark's gullet and a girl who was shot at sea lead the team to a smuggler who was running Cuban refugees and cocaine in a foundering ship.

A dead man with a slit throat and a partially burned face is discovered on a Miami beach, along with an unconscious young girl who was beaten and thrown into the ocean. The investigation leads Horatio to a prominent Florida family and its steely patriarch, who was once involved in a mysterious case that has plagued Horatio for years.

When a priest is found dead in his rectory after being brutally shot, Megan, Calleigh and Speedle must untangle a messy web of familial issues that lead to his death. Elsewhere, Horatio and Eric attempt to solve the emotional case of an exploded vehicle, which was home to a mother with child.

Horatio and his team must uncover the evidence in the brutal murder of an entire family in their own home. The only survivors are a blood-soaked toddler, and the father who's in surgery. The immediate assumption is that the mother is responsible – post-partum depression – but the evidence discloses a different outcome.