A dead man with a slit throat and a partially burned face is discovered on a Miami beach, along with an unconscious young girl who was beaten and thrown into the ocean. The investigation leads Horatio to a prominent Florida family and its steely patriarch, who was once involved in a mysterious case that has plagued Horatio for years.

Horatio and his team must uncover the evidence in the brutal murder of an entire family in their own home. The only survivors are a blood-soaked toddler, and the father who's in surgery. The immediate assumption is that the mother is responsible – post-partum depression – but the evidence discloses a different outcome.

An inmate at a massive Miami prison complex is stabbed to death in the prison yard. Shortly after Horatio arrives on the scene, a helicopter appears above the correctional facility. He immediately fears that the murder was a decoy to set up an escape. That's confirmed as three prisoners hop aboard the chopper and flee. As the investigation gets underway, the identities of the fugitives become known and a horrible realization sweeps over Horatio: two of the escapees are cold-blooded killers who already have their next victims picked out, and the other is a child molester who he recently put away.