The two young owners of a city bar are gunned down after hours and another man is wounded in the attack, which was allegedly committed by a masked gunman. Meanwhile, Calleigh's dad announces he is now a public defender and needs her help with a murder case in which a woman allegedly stabbed her boyfriend to death in his car with a screwdriver.

Delko and Alexx are nearly burned alive when they investigate the death of a hunter found shot near a supposedly controlled burn in the Everglades. The fire suddenly rages out of control and traps them, forcing them to take refuge under a tarpaulin. Later, a second body is discovered, and this time it's a young woman who looks to have been beaten to death. After bite marks are found on the victim's breasts, Horatio is led to believe a sex offender is behind the attack – and the fire.

After a small plane crashes at a Miami beach and the pilot dies, Horatio finds remnants at the crash site of chemical used in making cocaine, and it seems that the victim's business partner may have sabotaged the aircraft. However, when evidence suggests that the pilot may have died before the crash, the team investigates the victim's neighbors – all wealthy residents of a secluded cul-de-sac where lust, jealousy and greed are dangerous motives for murder.