While investigating the murder of man hired to make dirty bombs that terrorists intend to set off in Miami, Horatio finds the bloody fingerprint of his brother, Raymond, who he believed to be dead. However, when Raymond's son is kidnapped, he emerges from deep undercover and the estranged brothers must work together to save the boy. Meanwhile, while processing a crime scene, an unknown assailant holds a gun to Calleigh's head and, after a deadly confrontation in her gun lab, she is left doubting that she can continue as a CSI.

The team must find the connection between the two crime scenes; the killing of a drug dealer and the rape of a well-off family member.

Three suburban housewives on a girls' weekend in Miami are the prime suspects when the hotel's handsome pool boy is found murdered. When Horatio is tipped off that his team is facing a surprise efficiency review, he must trust Calleigh, Delko and Ryan to work together to find the killer. However, when they independently follow the evidence, each discovers that their analysis points to a different killer.

Eric Delko is at the bank, following an ATM taking his debit card, when three robbers wearing ski masks rush in. Delko knows he can’t win against the three robbers but when one of them tries to rape a girl it ends in a shootout. The security tape leads them to Miami University and to the robbers next target and Horatio manages to arrest one of them. The trail leads to a videogame named “Urban Hellraisers” and when Ryan Wolfe starts playing it, it turns the similarities between the game and the actual crimes are very big. It’s up to the team to catch the robbers before they commit a crime much more serious than the last one.

After a man is found not guilty of his wife's murder the CSI team finds evidence to the contrary.

The CSI team must try to find out who is trying to kill a young couple who are released from prison. The couple was made out to be “media darlings” and soon find that not everyone though of them as darlings. Calleigh must work with her ex-boyfriend to help solve the case.

The body of a local politician is found in an empty house. The entire neighborhood was upset that he was backing the use of eminent domain, allowing the government to force them out of their homes.

A murder and kidnapping becomes personal when DNA from a crime scene reveals that Natalia’s sister Anya is one of the kidnapped women they are looking for. The team finds a safe full of photos of missing women and they must find the photographer who was using his camera to lure the unsuspecting women.