The wife of a famous baseball player is brutally killed in her home and her philandering husband is charged with the crime. The jury on the case, as well as the accused and his defense, visits the house to examine the crime scene, but when the lights are dimmed, as they were when the victim was killed, and then turned back on, the ball player is found dead with a meat clever in his back and a note that reads "guilty." Now, as Horatio and the team find that the husband's defense team tampered with the crime scene, they must examine the evidence to find the couple's killers. Meanwhile, Horatio gets a call from Yelina, who tells him that her son, Ray, Jr., is missing.

As a huge tsunami heads directly towards Miami, a ten-hour warning gives citizens just enough time to evacuate the city. In the chaos, two people are killed in a parking lot and the evidence leads Horatio to discover a plot to rob a bank timed to take advantage of the evacuation. However, as the CSIs close in on the robbery already in progress, they find that it's a more elaborate crime than they previously thought. In the wake of the storm, Ryan and Alexx discover a body washed up from a local cemetery that may have a different cause of death than originally recorded. Meanwhile, Horatio suspects that Yelina is being physically abused by her boyfriend, IAB's Rick Stetler.

The CSIs must investigate when a pedestrian is killed after a man falls from a building and lands on him. Horatio and the team find that the victim found on the sidewalk is not the same man who fell from the building, but the unfortunate person he landed on. The CSIs discover that the fallen victim is in possession of a sex DVD involving a top Miami criminal judge and a woman with a sordid sex life. When the woman is found dead, the team must delve into the complicated personal lives of those in Miami's judicial system in order to find the killer.

During a routine traffic stop, a police officer is murdered and now Horatio and the team must track down the killer. The only witness to the murder is a civilian who was doing a ride-along with the officer, but who is now missing. Roadside evidence leads the CSIs to Missy Marshall, a teenage girl who was with the killer at the time of the murder. However, as the team searches for the civilian and the killer, they find that Missy may have been more involved with killer and the shooting than she is admitting. Meanwhile, Horatio and Rebecca's relationship is in jeopardy when they don't see eye to eye on a case.

Horatio's son goes missing when a prison transport is attacked. Upon learning the identity of Kyle, he is targeted in order to get at Lt. Caine, who must find him before it is too late.

Meanwhile, Ryan causes tension with his former colleagues when he is hired as an expert witness for the defense.

The investigation into a runway model's death leads Horatio to his son and his nemesis.

Kyle's mom shows up in Miami and she is the widowed wife of a billionaire. She wants Kyle back and will do anything to get him back.

Horatio heads to Los Angeles to hopefully clear Jesse's name, all while a former sports superstar is being investigated after a girl is found dead in his home...

When a suburban soccer mom is murdered, the CSIs uncover her family's dark past, while Delko continues his undercover mission.

When Horatio's ex-girlfriend is killed in an explosion, the team looks within their own department to find the killer.