Horatio battles the FBI and U.S. Marshals as he tries to uncover why a woman was murdered at the side of a pool at a hotel. The investigation begins shortly after the woman is found dead from two shots to the head. The evidence suggests that it was a professional hit man, which is strange enough, but the case becomes additionally puzzling when the Feds and U.S. Marshals get involved. Plus, the murder weapon is linked to a cold case that was orinially investigated by Yelina. Meanwhile, Calleigh talks to her dad about his drinking problem after she's called away from work to drag him out of a bar.

Horatio is quick on the scene when an armored truck carrying $3.2 million is robbed in a daring downtown heist. During the holdup, the driver is killed and Horatio guns down one of the two thieves. The other escapes with the loot, but the money turns out to be counterfeit. The team must figure out what happened to the bank's money before it was replaced with fake bills. Making the day even worse for Horatio, Yelina spies him with his niece and assumes the girl is his illegitimate child, not her own late husband's daughter.

After a small plane crashes at a Miami beach and the pilot dies, Horatio finds remnants at the crash site of chemical used in making cocaine, and it seems that the victim's business partner may have sabotaged the aircraft. However, when evidence suggests that the pilot may have died before the crash, the team investigates the victim's neighbors – all wealthy residents of a secluded cul-de-sac where lust, jealousy and greed are dangerous motives for murder.

The CSIs must find the killer after a young woman is pushed in front of a moving bus. Alexx finds a bruise shaped like a hand imprint on the victim's back, proving that she was pushed in front of the bus, and her boyfriend, Jay Seaver, is the prime suspect. When one of Jay's office rivals also turns up dead, Jay reveals that he has a psychotic stalker, Claudia, who he thinks might kill to please him. However, when Jay hires a lawyer to protect Claudia, Horatio suspects that Jay may be more involved than they thought. Later, a man's body is discovered down an elevator shaft in a nearby building, and there is evidence to link the victims to a common killer. Meanwhile, Calleigh's father seeks her help when he fears that he may have killed someone after a night of drinking, and Horatio assigns a new CSI, Ryan Wolfe, to the case.

A murder investigation takes Horatio and the team into the world of speed dating. Richard Laken is found killed by a tire iron outside a lounge following an evening of speed-dating. The team discovers his car is covered with acetone, which traces back to one of the female guests. She reveals that she dated Laken and he dumped her, so she doused his car with nail polish remover for revenge, but she didn't kill him. Now, when Horatio and the team learn that Laken recently witnessed a serious assault at a Miami Heat basketball game, they are on the hunt for two perps instead of one.

Evidence leads the CSIs to believe that someone started a massive fire in the Everglades in order to cover up a murder. Local prisoners are brought in as free manpower to help fight the wild fire in the Everglades. However, when a serial killer escapes the scene, Horatio must track him down before he strikes again. Meanwhile, the body of a local college student is found shot to death and the fire has destroyed the crime scene and the evidence. However, when the team uncovers an illegal moonshine operation and homemade ammunitions in the vicinity, the CSIs uncover the real reason why the boy was out there.

After a bitter custody battle, shots are fired outside the courthouse. Bullets fly and the target is the little girl's mother. Horatio goes after the father, who he suspects may not be the girl's biological father after all. However, when the mother's shady past is uncovered, the team finds that she has a lot of enemies who would like to take a shot at her. Meanwhile, Calleigh's father returns to the crime lab for her guidance but for an unexpected reason.

Horatio and the team are trying to figure out how to free an innocent young man after a harsh interrogation with Frank Tripp sends him to jail.

Horatio hunts for the man responsible for a brutal rape on a woman years back, after new DNA testing technology finds the convicted rapist innocent.

The CSI team must try to find out who is trying to kill a young couple who are released from prison. The couple was made out to be “media darlings” and soon find that not everyone though of them as darlings. Calleigh must work with her ex-boyfriend to help solve the case.

A cruise ship that is docked in Miami is the scene for a double murder. The team investigates the long list of potential suspects but soon find that the list is dramatically decreased when the CSI's find a large amount of money is missing from the victim's stateroom. Horatio and Marisol's relationship evolves.

After an accident where the driver was decapitated during a dangerous stunt, the evidence leads the CSI’s to believe it was more than an accident. While gathering the evidence, the CSI’s find they must go into the world of “sideshows.”

After a scalped body is found near a Native American casino, Horatio believes that the owners of the Casino and the County Supervisor may have had some involvement in the murder.

After the murder of a suspected carjacker the team discovers that he may have been involved with a formidable drug lord and was suspected of drug running off Miami's shores.

When the team is investigating the murder of a probation officer and a hostage situation, Horatio learns that the main suspect could be his son.

A serial killer is on the loose with a craving, making Calleigh its next victim, which also jeopardizes her ability to do her job.

The team uncovers the secret life of an unscrupulous FBI agent while investigating the murder of a young woman.

A man is murdered when someone drops a piece of slate off a bridge. The team tracks the slate to one of their own and Alexx's son becomes a suspect. Then to make matters worse Alexx finds him in a warehouse holding a bloody knife over his friend who happened to be the other suspect.

While Horatio and the team investigate a murder at a trendy store, Horatio finds that Julia's instabilities have turned her into a ticking time bomb.

When pirates take over a luxury yacht, Delko's future as a CSI is threatened just as his relationship with Calleigh moves to the next level.

An explosion in an upscale Miami eatery has the CSI team scrambling to figure out who would target a family enjoying a dinner out, and why...

A young man gets involved with a dangerous operation in an effort to rescue his girlfriend who's been brought to this country to work as an indentured servant...

One of Kyle's army friends tries to protect his girlfriend from an "honor killing" and winds up as the number-one suspect in a murder...

A serial killer taunts the CSIs by leaving them cryptic hints, and the longer it takes them to decode these puzzles, the higher the death toll rises, on the eighth season finale of CSI: MIAMI.

When the man who killed Horatio's wife breaks out of prison and goes on a rampage, the team tries to determine what he is after.

On the 200th episode Horatio must find an attacker and save a pregnant woman and hope he has an idea as to why she was attacked.

Horatio and Natalia's lives hang in the balance, as Horatio stands between Natalia and certain death. Meanwhile, it's a race against time for the team to capture escaped killer Jack Toller before he kills again.