Exposed as a criminal, sentenced to prison, and terminally ill due to long term kryptonite exposure, Lex Luthor escapes and assembles a supervillain team consisting of Cheetah, The Shade, Solomon Grundy, Star Sapphire, Copperhead, and Ultra-Humanite to take on the Justice League, calling themselves the Injustice Gang. The Joker also becomes part of the team, but on his own choice. However, this gang proves short-lived as its major weakness proves no match for Batman's wiles.

Exposed as a criminal, sentenced to prison, and terminally ill due to long term kryptonite exposure, Lex Luthor escapes and assembles a supervillain team consisting of Cheetah, The Shade, Solomon Grundy, Star Sapphire, Copperhead, and Ultra-Humanite to take on the Justice League, calling themselves the Injustice Gang. The Joker also becomes part of the team, but on his own choice. However, this gang proves short-lived as its major weakness proves no match for Batman's wiles.

Lex Luthor, on the run from the League, reactivates an old LexCorp project to stop the League - an android that can duplicate the powers of anyone it sees.

Even Superman is unable to defeat the android once it duplicates all of the League's powers. Only with the aid of J'onn, suffering a crisis of faith when he is overwhelmed by humanity's pettiness during a telepathic scan, can they turn Amazo against Lex.

The Justice League must deal with a prison break, unaware that prisoner John Dee is using the distraction to gain access to an experimental ESP machine and gain the power to manipulate dreams.

The Justice Lords, an alternate version of the League from a different dimension, capture their counterparts and plan to bring their own brand of justice to the new Earth.

The Justice League must escape from their imprisonment at the hands of the Justice Lords and defeat their counterparts with the help of an unlikely ally.

After Superman makes the ultimate sacrifice to save his fellow heroes, the Justice League and rest of the grieving planet must learn to live in a world without Superman.