When Melinda goes to visit friends who are experiencing problems with their house, she finds the ghost of six-year-old little girl who drowned. Melinda then tries to help the family of the little girl.

Jim has a ghost who died during surgery come to his dreams. Melinda and Jim find that the ghost, a supermodel, cannot cross-over as she wants to save her little sister from suffering the same destiny. Jim's friends are frightened by the crazy events that occur at his house.

The ghost of chef who died in a fire at a Chinese restaurant meets Melinda after the restaurant he died in burns for a second time. He demands that Melinda go out and find the person that really set the fire he was blamed for.

A high school baseball pitcher Justin finds that he is haunted by the former baseball star pitcher. The ghost is out for revenge on the coach who he blames for his death.

While Melinda is at the University’s botany lab she deals with some telekinetic events while dealing with a plant from Peru that is bleeding. Melinda finds that she must help a Doctor save herself.

Melinda finds that she must stop a ghost who doesn't want to be reincarnated again. Melinda finds out that someone knows her secret. Delia has second thoughts about dinner date.

Melinda gives a speech on her career at Grandview High. While she’s at the school she sees a group of cheerleaders who are having some mean and vicious things happening to them just as their cheerleading semi-finals are approaching in just a few days. Melinda discovers that the dead cheerleader can’t cross over and someone else has been casting spells on the squad.

A body goes missing from the morgue and Melinda searches for the body. When the ghost visits Melinda she finds she needs help from Professor Payne to figure it out.

Melinda and Jim become foster parents temporarily for a young girl whose mother is missing. The ghost of the mother comes to Melinda and tells her where Melinda can find her body. The mother confesses a secret to Melinda and Melinda and Jim set out to help the little girl.

Five accidents, and four signs, something else is going to happen. Melinda becomes concerned for the safety of the people she loves when a ghost prophet shows her visions of the future. The fellow Ghost Whisperer, who Melinda doesn't trust is still in Grandview.

Melinda visits the Mayor of Grandview and asks him to cancel the memorial dedication they are holding. She speaks to the ghost of a mail person and is looking for a young girl named Kristen. Later, Melinda and Professor Payne search for missing children after their Nanny says that they left with a man named Gabriel. Meanwhile, a mysterious man tries to get Melinda to stop helping the good guys.

Melinda helps a group of college girls after one of their friends dies and begins to haunt them. Melinda must get Rachel to believe she is not Bloody Mary.

Melinda's life is in danger when she tries to help the victim of a stalker.

Melinda and Professor Payne meet with another college professor who discloses that she had an affair with a student. That student just passed away after an accident.

Melinda becomes involved with a couple of ghosts who refuse to cross over after she finds that they are causing trouble for another couple. The ghosts make Melinda play a game of twenty questions.

Melinda is at the house of young boy named Riley and as they're hanging Christmas ornaments on the tree, Melinda tries to get him to open up about the strange things he has seen.

Melinda helps a ghost who blames Jim for his untimely death in an explosion.

After graffiti is repeatedly painted on Melinda's shop doors, she seeks out the town blogger convinced he is the one causing the mischief in an attempt to expose her. Melinda is forced to encounter the dark side of Grandview in order to help the latest ghost cross-over.

Professor Payne meets Elliot, the brilliant son of one of his old girlfriends. When Payne discovers that the boy is almost 10-years-old, he realizes he may be the boy's father. This angers his deceased wife. After watching Payne, Elliot, and the boy's mother, Melinda tells Jim she wants to have a baby.

Melinda meets with Carl, a detective she hired to trace her father's whereabouts after he left Melinda and her mother. Carl stops by the house to give her the little bit of information he collected on her father and something strange happens to him while he talks to Melinda.

Melinda discovers the truth about her family's past through a series of bodily possessions.

After being rescued by Jim from a fire at the Rockland University, Eli has a near death experience. Melinda becomes friends with Eli and soon discovers that they both have the same abilities.

Melinda reconnects with old high-school friends after one of their classmates dies mysteriously.

Melinda and Jim go away on a romantic cruise and Melinda comes into contact with an angry ghost who haunts a newlywed couple.

When a child's imaginary friend disrupts a wedding, Melinda tries to calm the ghosts causing chaos.

Melinda tries to help a man suffering from amnesia regain his memory.

Melinda helps a disillusioned ghost out with marriage problems.

Melinda will face her greatest fear as she embarks on a road trip with Sam. Along the way, they encounter some troubling incidents.

Melinda must deal with the spirit of an overbearing mom who is suppressing a deep and dark secret.

Melinda reveals her gift to Sam, but his reaction is not what she had expected.

Sam has a brush with death as he risks his life to save Melinda from harm.

A ghost causes problems for a television show that is filming in the Grandview town square.

As Melinda and Jim start making wedding plans, Melinda notices one of Ned's friends from school has a ghost attached to her which thinks it's a vampire.

Jim and Melinda's wedding is overtaken by an ambitious wedding planner while Melinda deals with dreams that seem to threaten her child. Elsewhere, Eli's ex, Zoe, is caught up in a book sale with tragic consequences.

Melinda looks into a chain email that appears to be preying on the citizens of Grandview.

Melinda helps a dead doctor who is reliving a surgery that went wrong.

Melinda help Eli with a patient who is being haunted by his sister. Meanwhile, Jim and Melinda have concerns over something Aiden has been seeing.

Melinda is pulled into a murder mystery by a real estate power couple when a ghost leads her to his own corps.

When the ghost of a high school boy accuses a Grandview cop of murdering him, Melinda is convinced that his death wasn't a mere skateboarding accident.

Ned's Occult Anthropology professor is stalked by the ghost of a secret admirer. Ned tries to use a Ouija board to help solve the mystery but instead is warned that someone they know is going to die soon.

Dark forces are fighting for the soul of a little girl that cannot escape the haunted house she has been trapped in for years.