Melinda Gordon just got married; during the dinner she sees something being drawn on the window and she knows it's a ghost. But for the first time, the ghost comes inside her house and that unsettles her. Despite being afraid, she tries to help him reunite with his family and pass along the message he needs her to say.

A boy who was killed in a collision with a train wants Melinda's help to ensure his mother that his death was not caused by her.

The identical twin sister of a teenage girl requests Melinda to help her apologize to her sister who is a psychiatric patient.

Melinda encounters the ghosts of three boys who died in the fire of an orphanage. They must cross over prior to the demolition of the building holding them inside.

Melinda helps an angry teenage ghost and discovers the secret that is likely to shake up the ones left behind by him.

In a hospital, Melinda encounters a woman who wants to determine what caused her death during a surgery.

An evil spirit is haunting Jim, causing him to begin doubting his sanity. Melinda must help this spirit, even though he is dangerous, in order to help Jim. .

The spirit of the mother of a teenage boy attempts to communicate with her son via white noise. Melinda must find a way to get her messages across.

A ghost of a bride who didn't make it through her wedding night is back with a vengeance haunting her husbands new fiancée to the point of her leaving him at the alter.

Melinda worries that Andrea is being influenced not to cross over. Melinda seeks the help of an expert in history and the occult in helping to identify the wide brimmed hat man.

A rock and roll enthusiast expands his love to living teens by tormenting them into stealing. Melinda must also deal with the ghost of her scheming ex-boyfriend.

The ghost of a man who was buried in the wrong grave starts to haunt a cemetery as someone else’s wife is coming to mourn him every night. Melinda must reconcile the man with his hostile wife and daughter in order for him to be able to cross-over.

Jim has a ghost who died during surgery come to his dreams. Melinda and Jim find that the ghost, a supermodel, cannot cross-over as she wants to save her little sister from suffering the same destiny. Jim's friends are frightened by the crazy events that occur at his house.

Melinda and Jim's first camping trip is interrupted as Melinda helps the ghost of a woman who left her husband and young daughter. Before the woman can cross over Melinda must find the woman’s daughter and help her to learn the truth about her parent’s past in order for her to be safe now.

The ghost of chef who died in a fire at a Chinese restaurant meets Melinda after the restaurant he died in burns for a second time. He demands that Melinda go out and find the person that really set the fire he was blamed for.

When Melinda meets a nightclub waiter who has not played his guitar since his friend died, she finds that he is being haunted by two ghosts.

A high school baseball pitcher Justin finds that he is haunted by the former baseball star pitcher. The ghost is out for revenge on the coach who he blames for his death.

Melinda's Jeep breaks down on a deserted road and a young woman who owns an auto shop comes by to help. Melinda meets a ghost who comes to her in the form of a skeleton. Melinda must first decipher the mysterious code that is linked to the drag racing society. Melinda finds that Ned is involved with the society and needs his help. Ned lies to his mom and sneaks out to go to the drag races. At the end the ghost finds closure and crosses over into the light.

Melinda gives a speech on her career at Grandview High. While she’s at the school she sees a group of cheerleaders who are having some mean and vicious things happening to them just as their cheerleading semi-finals are approaching in just a few days. Melinda discovers that the dead cheerleader can’t cross over and someone else has been casting spells on the squad.

Melinda accompanies Delia to the local jewelry store so she can get her newly refurbished engagement ring. An armed robbery occurs while they are in the jewelers. Later, the ghost of jewelry salesman visits Melinda and she must help him make things right again.

A body goes missing from the morgue and Melinda searches for the body. When the ghost visits Melinda she finds she needs help from Professor Payne to figure it out.

Melinda and Jim become foster parents temporarily for a young girl whose mother is missing. The ghost of the mother comes to Melinda and tells her where Melinda can find her body. The mother confesses a secret to Melinda and Melinda and Jim set out to help the little girl.

Melinda helps Ned deal with a ghost who had just put a scare into him. Melinda also helps a ghost who appears to without any clothes on. Delia sees that Melinda is once again talking to herself and Melinda decides it’s time to share her gift with Delia.

Melinda meets a man who has the same abilities to see and talk to the dead. Melinda later learns that he has a different plan for the dead. A ghost enlists Professor Payne to help Melinda.

Five accidents, and four signs, something else is going to happen. Melinda becomes concerned for the safety of the people she loves when a ghost prophet shows her visions of the future. The fellow Ghost Whisperer, who Melinda doesn't trust is still in Grandview.

Melinda visits the Mayor of Grandview and asks him to cancel the memorial dedication they are holding. She speaks to the ghost of a mail person and is looking for a young girl named Kristen. Later, Melinda and Professor Payne search for missing children after their Nanny says that they left with a man named Gabriel. Meanwhile, a mysterious man tries to get Melinda to stop helping the good guys.

After being rescued by Jim from a fire at the Rockland University, Eli has a near death experience. Melinda becomes friends with Eli and soon discovers that they both have the same abilities.

Melinda reconnects with old high-school friends after one of their classmates dies mysteriously.

Melinda tracks down a ghost who is targeting girls on a social-networking Web site.

Melinda investigates the sudden death of a high-school athlete whose ghost is following a family that is not her own.

Melinda tries to help a man suffering from amnesia regain his memory.

Sam may discover Melinda's secret and rethinks his relationship with her after she's caught in several lies.

Sam has a brush with death as he risks his life to save Melinda from harm.

A young woman in Eli's apartment building is being haunted.

A ghost causes problems for a television show that is filming in the Grandview town square.

Jim and Melinda's wedding is overtaken by an ambitious wedding planner while Melinda deals with dreams that seem to threaten her child. Elsewhere, Eli's ex, Zoe, is caught up in a book sale with tragic consequences.

Melinda looks into a chain email that appears to be preying on the citizens of Grandview.

When the ghost of a little girl who passed away from leukemia befriends Aiden and threatens Melinda to stay out of her way, Melinda worries for her son's safety.

When Melinda discovers a family secret, madness grips the hospital and the town when a ghost who is making no sense haunts a patient who's making even less. Melinda must unravel the mystery behind a madness that grips Jim's (David Conrad) hospital - and the rest of Grandview.

Damon is a graphic (comic) novelist; kind of hip and edgy, he is being haunted by the ghost of a teen boy as he is ready to release his new novel and strange things start to happen to him and the ghost is tormenting him until Melinda can help him find out who is trying to stop his work, while the things the ghost does to Damon are predicted in his comics.