Sally Stukowski and her partner make their move, attacking the Regents and using an artifact to trap them in a building and bring it down around them.

While Pete and his mother Jane try to determine the origins of their mysterious opponents, Myka and Claudia travel to Portland to stop a girl who can apparently vaporize anyone she hates with blasts of radiation.

As Sykes begins his end game, the agents discover that Helena is still alive... and teaching high school literature. Meanwhile, Jane reveals the full extent of her plan but one agent will lose their life carrying it out.

Pete and Myka race to stop Sykes from using his own cache of artifacts to destroy them and the Warehouse.

While Claudia tries to help a friend and gets unexpected help, Pete and Myka investigate an artifact that causes crowds to see certain individuals as monsters... and attack them.

With the fate of the world in their hands, Pete and Myka's only hope of finding a cure to the Sweating Sickness is a drunken history professor. Meanwhile, Steven and Claudia enter Artie's subconscious in an attempt to bring him out of his coma before he fades away for good.