While Pete and Myka travel to Las Vegas to investigate two deaths where the people inexplicably fell from great heights, Claudia and Steven investigate two jockeys in London who went into comas after winning their races. Meanwhile, Artie gets a visitor to the warehouse.

H.G. has created a new life for herself in Wisconsin, but calls in the agents when she comes up against an unidentified artifact. Meanwhile, Abigail joins the others on the floor of the warehouse to track down the source of mysterious tremors that threaten to destroy the building.

Someone in a gated community is using an artifact to extract vengeance and Myka and Pete go to investigate. Meanwhile, Artie and Claudia help a teen suffering from dangerous visions, and Steven and Abigail clean up the warehouse.

Pete, Myka, and Charlotte must track down Sutton, the only man who knows where they can find Paracelsus and exchange the Philosopher's Stone for the stele that will free Claudia from her bronze imprisonment... before she disintegrates.

Pete and Myka capture Paracelsus but not before he makes himself immortal. When Myka's cancer becomes worse, Pete must make a deal with Paracelsus to cure his partner. Meanwhile, Claudia receives some startling news from Artie.

When Paracelsus takes control of Warehouse 13, it proves to only be the first step in his plan to recreate the entire world in his image. To stop him, Pete and Myka must follow him back through time to 1541 and prevent him from killing the Regents and becoming the permanent master of the Warehouses.