The agents hope to spend a weekend relaxing until an artifact gets in the way.

The team tries to track down their rogue member, and discover the artifact they have is unexpectedly powerful. Meanwhile, Claudia wonders about her future with the Warehouse team and Pete must choose between Kelly and the mission.

While in Denver, Myka picks up the trail of the counterfeiter who killed her former partner, Sam Martino. Meanwhile, Artie, Claudia, and Steve interrogate a dog that witnessed the theft of an artifact.

As Sykes begins his end game, the agents discover that Helena is still alive... and teaching high school literature. Meanwhile, Jane reveals the full extent of her plan but one agent will lose their life carrying it out.

While Pete and Myka go to Toronto to investigate an invulnerable hockey player, Steve helps Artie track down stolen artifacts while Claudia meets with Mrs. Fredericks to discuss her future as a warehouse guardian.

Pete, Myka, and Claudia set off to rescue their loved ones when Brother Adrian sends them deadly artifacts. Meanwhile, Mrs. Frederic and Steve travel to Rome and learn Adrian's dark secret.