A woman kidnaps Artie and insists that he help her recover her brother... who was lost in an artifact-related experiment 12 years ago.

The team discovers that MacPherson is auctioning artifacts he has siphoned from the Warehouse shelves.

In the season two premiere, we pick up right where we left off. MacPherson has blown Artie to smithereens, and disappeared. Is Leena really a traitor? Where has Claudia gone? How will Pete, Myka and the Warehouse fare without Artie? What other havoc did MacPherson wreak when he was alone in the Warehouse? And is there yet a new villain on the horizon?

When Mrs. Frederic is stricken ill, the agents must search for a cure before it's too late. Their quest takes them to Egypt and the long-lost Warehouse 2.

When we last left agents Myka Bering and Pete Lattimer at the conclusion of season 2, Myka had decided to leave the top secret team with little to no warning. As season 3 begins, Artie fills Myka's shoes with 'The New Guy,' which also happens to be the name of the season premiere episode.

Pete and Myka race to stop Sykes from using his own cache of artifacts to destroy them and the Warehouse.