While trapped on an island, Joe and Courtney remember old times, then repair a raft to escape. However, Courtney twists her ankle before they depart the island. An old nemesis of Victor's traps him and Mary in the back of moving truck and plans to kill him. After failing to use laughing gas to overpower him, Mary personally appeals to the man, who agrees to help them because of his hatred toward Mr. Kanelos. After thanking Karen for her support during his withdrawal, Frank and Karen realize no one's heard from Joe and Courtney in Greece. They contact Mrs. Kanelos, who denies they are there.

Matt realizes Karen has not told Joe he's not Neil's biological father. Karen tries to help Joe find a cure for Neil, but he shuts her out. Frank dissuades Courtney from blaming Karen for their lost child. They begin to make love, but when Courtney doesn't want to use protection, Frank stops because he doesn't want her to get pregnant again and risk her health. At Julie's trial, Cooper recants his testimony and claims Rachel and Chris threatened into him confessing to the murders. Rachel, Chris and Julie lash out at Kevin and Eve, but privately Chris places the blame for Cooper's botched testimony squarely on Rachel.