When they blow the capture of a wanted felon, Starsky and Hutch each blame the other, and lay down a bet to see whether or not Hutch can successfully elude Starsky for a whole weekend. But the exercise in hide-and-seek becomes more than just a game when Starsky realises that Hutch has unknowingly eaten contaminated soup, and could die from the potentially lethal botulism poisoning. It's a race against time as Starsky struggles to locate Hutch to warn him, but Hutch, unawares to the poisoning, assumes it's all part of Starsky's attempts to draw him out, and dons a number of disguises in order to stay one step ahead...

Responding to a jewellery store robbery, Starsky is distraught when he accidentally shoots an art student caught in the cross-fire, costing the girl her sight. Guilt-stricken, he forcefully strikes up friendship with the blinded young woman, without confessing that he's the law officer that caused her to loose her vision. But their subsequent relationship soon proves to be very dangerous, as someone seems determined to keep him away from her, and Hutch comes to question just how much of a chance by-stander she really was in the incident...