A suspicious House fire, an Amber alert during a carjacking and Fatal car crash caused by texting while driving introduce the members of LAPD Downtown, Station 77 and Trauma One.

The hunt for the shooter begins yielding unexpected results. Station 77 deal with a chemical fire, a heart attack on a bus and a scaffold rescue.

Stacey's abusive father appears out of nowhere. Sgt Mandell gets involved in an elder abuse situation and station 77 rescue a trapped hiker with a broken leg, attend a multiple vehicle freeway smash and rescue a young boy out of a drain.

A sniper is targeting Paramedics. Rescue 77 must still respond to 911 calls despite the additional risk.

The sniper situation continues but for rescue 77 it has to be business as usual.