Brenda must reopen the case of a murdered psychiatrist when the man claiming to have committed the crime gives a statement that doesn't quite match the actual events. Based on evidence of the man's acquaintance with the doctor, Brenda believes there is a cover-up and sets out to unearth the truth. Willie Rae throws a roadblock in her path when she pops in for a visit, which actually appears to be an attempt to dump Brenda's handful of a niece onto the newlyweds during for the duration of summer break.

The conviction of a woman found guilty of poisoning a banker is overturned when a laboratory essential to proving the case comes under scrutiny. The subsequent re-trial forces Brenda to ask Provenza's former partner for help tying up loose ends. Unfortunately for the team, more scrutiny occurs when they all discover Provenza's former partner is no longer the man he used to be. The importance of the case may ruin Brenda and Fritz's planned vacation.

In a case that could carry national security implications, three soldiers are gunned down outside an LA club two days after returning home from duty in Afghanistan. Brenda’s investigation puts her on a collision course with Major Edward Dorset (guest star Gary Cole), a military liaison officer.

Brenda seeks Capt. Raydor's help in an investigation of possible police brutality; Brenda's attorney starts deposing the squad about the Baylor case.

In the series finale, we bid a final farewell to Brenda Leigh Johnson. When a young man calls 911 to report seeing someone being buried in Griffith Park, police find not only her remains, but those of several other women who were kills as far back as two years ago. Brenda immediately suspects Philip Stroh and, despite departmental restrictions, sets out to finally tie him to the murders. Meanwhile, the witness who called 911 makes Brenda look at her life and future.

Stay tuned to the next show, Major Crimes, which will pick up from the moment The Closer ends. A large portion of the characters are moving to the new show. to work under the new supervisor of Major Crimes, Captain Sharon Raydor.