Meg's exciting European adventure comes to a halt when she is kidnapped; Stewie and Brian embark on an action-packed rescue mission..

When Brian discovers that Carter Pewterschmidt’s pharmaceutical company is withholding the cure for cancer from the public in order to gain more profit, he and Stewie plot to expose the big secret that could change the world. Meanwhile, Quagmire reveals a hair-raising secret of his own.

In order to "save" Stewie from autism, Peter and Lois decide not to vaccinate him and then proceed to convince the rest of Quahog to follow suit. Stewie runs away to save himself from diseases until Sean Penn swoops in to save the day and brings vaccines to the whole town.

Peter becomes the temporary principal at the high school, and Meg uses his new power to get even with her bullies. Meanwhile, Brian and Stewie open a bed & breakfast that quickly turns into a brothel.