Peter and Brian’s friendship becomes strained after Brian begins dating one of Meg’s high school teachers. Peter finds a replacement friend in James Woods, who is visiting Quahog because of a suggestion to rename James Woods High after Dr. Martin Luther King Jr.

After Brian has a near-death experience in the hospital, he decides to lead a new life. He ends up getting a nightly singing gig with Frank Sinatra Jr., but his new lifestyle doesn't last very long. Meanwhile, Meg, after joining a new after-school group, pretends to be a lesbian.

When burglars break into the house, the Griffins take cover in the attic where they discover Peter has built a 'panic room'. They go in it, and Peter tells them about his history. They send Meg for food but the burglars catch her. The rest of the Griffins stay behind and Peter accidentally floods the room and they're going to drown. Luckily Joe gets them out and we find out Meg has been accused of sexual harassment by the burglars.

Meg can't find a date to her junior prom, and even though he is dating Jillian, Brian ends up going with Meg. At the prom, Brian gets drunk to make the night pass, but ends up making out with Meg. Meg begins to think of Brian as her boyfriend and becomes obsessed with spending every moment with him. Meanwhile, Peter, Cleveland and Quagmire join the police force to help Brian.

Lois runs for mayor of Quahog, though she doesn't become the front-runner until she dumbs down her political views. Once in office, she becomes corrupted with the power that she now holds, and begins accepting bribes so that she can buy herself expensive things. Meanwhile, Peter comes to enjoy being the "first lady" of Quahog, and all of the perks that go along with it.

After Quahog is hit by a flood, Meg winds up in the hospital in a coma. When she wakes up and sees a cute med student, they immediately hit it off. Overprotective of his daughter, Peter is determined to drive the med student away. That is until Meg reveals that she is pregnant.