After buying a brain-damaged horse, which causes over $100,000 worth of damage, Peter participates in medical experiments to make some extra cash. One of the genes he is injected with turns him gay, which later results in him leaving Lois for another man. Although the family is crushed, they quickly realise the most important thing is that Peter is happy.

Lois gets a job working for FOX News and has to do a report on a liberal filmmaker. However, she loses the job when her story implicates a conservative radio host.