Stan Smith uses his CIA skills to help 13-year-old son Steve win class president and the heart of the hottest girl in class, Lisa Silver. But when being class president makes Steve mad with power, Stan must jump in to save the day. Meanwhile, Roger, the alien Stan saved from Area 51, helps 18-year-old Hayley with her school paper. In return, she hooks him up with boatloads of junk food to curb his sweet tooth. Unfortunately, some Chocodiles send him over the edge and a sugar crash prohibits him from finishing one of her papers, forcing Hayley to pick up the pieces. And Klaus, the goldfish with the brain of a German guy, pines after mother Francine. Unfortunately for Klaus, the closest he'll ever get to a date with her is the spin cycle with her sports bra.

Stan Smith is mad because after getting his wife a job (or "hobby") as a Real Estate agent, she makes more money than him. In the meantime, his daughter Hayley ran a program that helped the homeless, and Stan's son Steve had an idea to have a Bum Fight program. To get back and to try to gain more money than his wife, Stan takes Steve's idea and starts a Bum Fight Night where he takes bets and treats the homeless like wrestlers. But with the homeless petition, Stan has to end up fighting like a homeless man himself.

Hayley comes home from a Green Party rally with her hair dyed green, instigating a fight with Stan. While she's sleeping, Stan cuts her hair (for her own good, of course). After learning of what Stan did, a wigged Hayley defies her father yet again by moving into the van of her new boyfriend. When Stan cuts her off financially, she gets a job as a waitress in a strip club, which pushes Stan right off the edge. Meanwhile, Steve tries to pass Roger off as his disfigured sister in order to cop a feel with a female classmate.

When Stan forgets his anniversary, he arranges to have 20 hours of Francine's memory erased, but the CIA temp on duty accidentally erases 20 years. Francine, having reverted to her wild child days, moves into her old apartment with Hayley as a roommate, and ends up going to a festival with Hayley's boyfriend. Meanwhile, Steve asks a good-looking girl out, but needs his wingman, Roger, to "jump on a grenade" for him and date her ugly cousin.

Stan invites his boss over for dinner, but the Smith family fears getting caught hiding Roger. After a close-call, Roger goes into a coma, making everyone thinking he's dead. After the family disposes of his body, Roger tries to get back home, but he ends up in another risky situation with the CIA.

Francine decides to throw a block party to get in touch with the neighborhood. Stan learns his new neighbors are Iranian and immediately suspects that they are terrorists. To prepare Steve for living near terrorists, Stan makes Steve join a group of scouts, who turn out to be trouble makers. Roger is convinced he possesses hidden alien powers and is determined to find out what they are.

Stan goes to great lengths to compete against his rival, Chuck White, and become the new deacon of their church. Meanwhile, Roger's "temporary problem," which Stan tries to use to his advantage, causes all sorts of problems for Steve, Betsy, the rest of the family, and eventually, Stan.

Stan finds Deputy Director Bullock, his supervisor, starting a relationship with Hayley. However, he can't risk saying or doing anything about it because he's up for a promotion at the CIA. Meanwhile, Steve finds Dick Cheney's BlackBerry and uses the contact numbers to play pranks on political figures from around the world.

When Steve brings home a permission slip to take sex ed at school, Stan flips out and demands to teach it himself. However, after Stan unrealistically explains the birds and the bees to Steve, he gets into an accident that causes him to take matters into his own hands. Meanwhile, Roger becomes a bartender in hopes of making something of himself.

When the CIA organizes a father-son baseball game, Stan is determined to show his co-workers that his son is masculine and athletic. Unfortunately, Steve is a geek, so Stan decides to lie and ditches him. But after getting a taste of his own treatment at work, Stan turns to Steve and his sci-fi knowledge to help capture a cyber-terrorist. Meanwhile, Roger goes incognito in a desperate attempt to interact with humans.

When Stan's father passes away, Stan reveals his real father is actually Jack Smith, a super suave spy. Jack convinces Stan to quit the CIA and work with him at the Scarlet Alliance, an ultra-secret spy group. Francine is upset with Stan, who is busy training with Jack for a mission involving uranium, artwork and terrorists. But when the FBI shows up at the Smiths' house looking for an international jewel thief, Francine suspects Jack is the fake.

Stan has to throw a party for his boss and assumes his wife Francine will do all the work, but she refuses. With Stan as party planner, the event turns into a disaster. As a result, Stan's boss relocates Stan and his family to Saudi Arabia, where they quickly get a taste of life on foreign ground. As American and Arabian social norms clash, gender wars heat up.

As the Smiths continue to live in Saudi Arabia, Stan is fully enjoying the male-dominated society, while the rest of the family struggles with the different social norms. Meanwhile, Francine's musical expos on gender roles gets her into trouble, and a brush with death leads the Smiths to return to the United States.