The entire CSI team investigates a disappearance at a local university. A young woman vanished, seemingly off the face of the earth.

Grissom and his team investigate a casino heist during which innocent victims were shot, while Catherine and Sara are called to the scene of a murder in a remote part of the desert.

Grissom investigates the murder of two men that leads him to a new encounter with Lady Heather. Catherine is desperate to find out what lead to the near death of her daughter and why her ex, Eddie, disappeared.