Catherine is ordered by a kidnapper to accompany a man who is to deliver $1 million in ransom to him or else he will kill the man's mistress.

Jane Galloway lives in fear. Her doors are triple-locked. Every shade is drawn. The bathroom window is nailed shut. An alarm system is activated. Who killed Jane, and how could the murderer have possibly entered, and left, the house?

Grissom investigates when a woman vanishes while taking part in a magician's act. The female volunteer is placed inside the Amazing Zephyr's "Chamber of Doom" and the illusionist thrusts swords through the box. When it's opened, she's gone---and doesn't reappear in her seat as she's supposed to. Only traces of blood are left inside the chamber. Clues lead the CSIs to an eerie, decrepit mansion filled with secrets. Elsewhere, a rock star's death on a band bus appears to be the result of an overdose, but Catherine uncovers evidence that points to murder.

Warrick investigates the drive by murder of a young girl in his old neighborhood. The girl's father is a friend and mentor of Warrick's as well. Warrick struggles to control his emotions to the point where Grissom pulls him off of the case. Nick tackles the murder of a computer company employee. The only supects are the three other employees in the building.

Two couples meet in a bar and one of the couples is murdered. When a second couple is murdered in a similar fashion the team suspects a pair of serial killers are on the loose. The case is complicated by leaks to the press and a judge reluctant to issue a warrant. Catherine gets some troubling news about her father's murder trial.

Three little CSIs (Grissom, Sara, and Nick)respond to an electrocution at a casino. The casino is hosting Japanese antiquities. The electroctution is just a ruse to steal the central piece of the exhibit. Catherine and Warrick deal with a vampire murder.

A wild night in Las Vegas has the CSIs simultaneously investigating four fatalities. Greg Sanders' first day in the field has him assisting Grissom's investigation of a fatal nightclub shooting. Meanwhile, Catherine probes into the death of a stripper found dead in a hotel room, while Sara and Nick look into the strange case of an "alien" body found near Area 51.

The CSIs come across an abandoned military compound being used by a small cult. The CSIs grow suspicious when they see that a mass suicide has taken place, but only 11 of the 12 beds are occupied.

A high roller who spent the night with a woman he had just met is found dead on the loading dock of the casino where he was staying. The investigation reveals that the victim won $10,000 in a pool game and was an assistant to a respected movie producer.