A wealthy donor to the university makes Leonard consider how far he's willing to go for the sake of science.

When Sheldon is forced to take his vacation, he goes to work with Amy in her neurobiology lab.

Sheldon battles Kripke for a coveted office at the university. Penny receives a very unusual gift from Amy.

Sheldon goes to Vegas to win money for science. Also, Penny and Bernadette take Amy wedding dress shopping, but her terrible choice entangles them in a web of lies.

When Amy doesn’t have time to work on super-asymmetry, Sheldon goes to great lengths to ensure she’s available to work with him even it if means accidentally sabotaging her career in the process. Raj doesn’t want Howard to join him in hosting a show at the planetarium.

Leonard is caught between a rock and a hard place when he's responsible for distributing extra grant money. Bernadette turns the backyard playhouse into a hideaway from Howard and the kids.

Penny and Leonard organize a paintball game that results in mayhem when Sheldon is jealous of Amy. Also, Raj catches Anu with her ex-boyfriend, and Stuart gets cold feet when Denise hints at the possibility of them living together.

Sheldon and Amy are thrilled when their super asymmetry theory is proven by two physicists, until they try to kick Amy off the Nobel nomination. Also, Bernadette gets one of her drugs approved at work and wants a reluctant Penny to head the sales team.

When competitors Pemberton and Campbell charm America on a publicity tour, Sheldon and Amy try to bring Nobel laureates Kip Thorne, George Smoot and Frances Arnold to their side. Also, Halley's fear of the dark causes opportunity and conflict at the Wolowitz home.

The concept of what it would mean for women everywhere if Amy were to win a Nobel Prize causes Amy to have a meltdown. Also, Howard and Raj try to relive the good old days after Howard buys a scooter that looks like the one he had years ago.

Raj is worried people won’t take him seriously in his own field after publishing a paper that suggests he may have discovered alien life. Also, Leonard wants to be the principal investigator on a plasma physics study.

Kripke has proof that Dr. Pemberton plagiarized his thesis in college, and Sheldon and Amy aren't sure if they should turn him in or not. Meanwhile, Howard learns that Bernadette wasn't the only waitress at the Cheesecake Factory who had a crush on him.

Sheldon and Amy await big news. Meanwhile, Penny and Leonard have some big news of their own. Also, Howard and Bernadette face the stressful challenge of leaving their kids for the first time and Raj makes a new friend, as the gang travels together into an uncharted future.