When they're invited to present at a physics conference, Sheldon's reluctance to share the credit leads to a tiff between him and Leonard, and Penny's intervention only exacerbates the situation.

Sheldon creates a scientific procedure for making friends.

A Christmas visit from his mother has Leonard discovering she's kept a lot of news from him that she shares with Sheldon and worrying if she'll approve of his romance with Penny.

Leonard is aghast to find out a secret of Penny's: she believes in psychics. Meanwhile, Sheldon tries to assist Koothrappali in picking up a girl at a university mixer.

When their apartment is robbed, Leonard and Sheldon turn to their friends to create a state-of-the-art security system.

Sheldon's search for the answer to a physics problem leads him to work at the Cheesecake Factory with Penny.

Leonard tells Penny about how he met Sheldon for the first time...and what happened to the elevator.

Realizing he will not live long enough to download his consciousness into a robot body, Sheldon tries to extend his life span.

Leonard realizes he’s the only one without a girlfriend, while Sheldon wants to get rid of his.

A wealthy donor to the university makes Leonard consider how far he's willing to go for the sake of science.

Sheldon becomes concerned when everybody begins to hang out at Raj's apartment and discovers Leonard is the center of the group.

Sheldon is baffled by Wolowitz's magic trick. Meanwhile, Leonard realizes dating Priya may make it impossible to continue being friends with Penny.

When Leonard spends too much time in the shower with Priya, Sheldon charges Leonard with two violations of the roommate agreement. However, before he can get too far, Priya uses her skills as a lawyer to nullify the charges due to the agreement's vague wording, much to Sheldon's dismay. When the guys take advantage of Priya's skills in order to eat Greek food on pizza night, Sheldon goes to Penny, who invites him to a girls' night out with Amy and Bernadette, which Sheldon agrees to after Penny mentions that they may be talking trash about Priya. After the girls drink some cocktails, they decide to take Sheldon dancing, which Sheldon reluctantly goes along with. After dancing, Sheldon takes an intoxicated Amy back to her apartment and as well as talking about Priya, meets a monkey who is addicted to smoking cigarettes. Amy tells Sheldon not to give in to Priya's law skills, before kissing him and going to her bathroom to vomit.

When Howard finally breaks the news to his mom that he's engaged to Bernadette, it lands her in the hospital.

Penny is worried with how damaged her friendship with the guys will be in the aftermath of her sleeping with Raj while Sheldon becomes the leader of the paintball team.

A fight between Sheldon and Penny leaves Amy caught in the middle, while Leonard tries to spice up his long-distance relationship with Priya.

Sheldon and Leonard get invited to a party at Wil Wheaton's house, and Howard gets an out-of-this-world opportunity.

When Wolowitz gets to work with Stephen Hawking, Sheldon is willing to do anything to meet his hero.

After the guys throw Howard a bachelor party, Bernadette reconsiders marrying him after learning about his sexual history.

The fifth season ends with Howard and Bernadette deciding to get married before his NASA mission, causing the gang to scurry into overdrive in an effort to stage the wedding. NASA astronaut Mike Massimino has a cameo as himself.

Amy feels threatened when Sheldon hires a young female assistant, and the pressure of being in space takes its toll on Wolowitz.

When Wolowitz returns from space, he doesn’t get the hero’s welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.

The girls get involved when Leonard, Sheldon and Raj compete for tenure at the University.

When Leonard receives an exciting opportunity to work overseas, Penny and Sheldon are thrown for a loop. Raj and Lucy's relationship comes to a crossroad.

Amy starts working at Caltech which causes friction with Sheldon. Howard agrees with Sheldon who mentions this to Bernadette causing a big fight for the Wolowitzes.

Leonard buys a dining room table and it causes Sheldon to reevaluate the changes in his life. Meanwhile, Wolowitz is offered a chance to go back to space and Bernadette struggles with whether or not to encourage him.

Sheldon faces a personal crisis after deciding he’s wasting his time with string theory. Meanwhile, a double date between Raj, Emily and the Wolowitzes ends in embarrassment for Howard.

Personalities collide when Sheldon and Leonard’s mothers finally meet. Meanwhile, Howard finally decides to “man up” and do his fair share of the housework – but not without a little help from his friends.

Leonard confronts the woman he kissed on the North Sea in an attempt to set Penny's mind at ease. Also, Sheldon films a special episode of "Fun with Flags" after his breakup with Amy, and Bernadette feels guilty about withholding a secret from Penny.

Sheldon, Wolowitz and Koothrappali post an online advertisement to find Sheldon a new girlfriend. Also, when Amy is coy with details about a guy she is dating, Penny and Bernadette decide to spy on her.

The gang goes to a wine bar and runs into Penny’s old boyfriend, Zack. Also, Bernadette gets stuck spending the evening with Sheldon when she can’t go wine tasting with the group, and things don’t go as planned when Koothrappali introduces his new girlfriend, Claire.

Chaos ensues when Leonard’s recently divorced parents, Alfred and Beverly, and Sheldon’s devoutly religious mother, Mary, come to town. Also, Wolowitz and Koothrappali think the government is out to get them when they are contacted about their guidance system.

The gang is concerned when Sheldon’s former admirer, Dr. Ramona Nowitzki, resurfaces while Amy is away at Princeton.