Meredith og teamet gjør alt for å hjelpe Owens søster, mens Bailey må jobbe for å renovere Grey Sloan Memorial etter den dramatiske brannen. Samtidig blir legene introdusert for flere nye ansikter som krydrer den nye hverdagen ved sykehuset.

Jo gjør et overraskende valg når det gjelder Alex. Samtidig sliter Meredith med å lage en plan for Owens søster. Og Andrews søster, Carina, driver med kontroversiell forskning som fører til en sjokkerende oppdagelse.

Den berømte Dr. Harper Avery kommer til Grey Sloan, og hos Bailey er nervene er på høykant. Samtidig dukker et kjent ansikt fra Merediths fortid opp, og Amelia prøver å holde på en hemmelighet.

Amelia konfronterer en vanskelig situasjon. Meredith må takle konsekvensene av samtalen med Nathan, mens Maggie er på en litt pinlig familiemiddag.

I et flashback til Irak i 2007, får vi oppleve hendelsene som førte til Megans kidnapping. Og tilbake i nåtiden bringer det opp gamle sår hos Owen og Megan. Episoden "Danger Zone" er regissert av norske Cecilie Mosli.

Owen and Teddy have to deal with the surprise arrival of Megan Hunt, who knows nothing about their situation. Catherine preps for her first surgery back on a war veteran who’s not emotionally prepared for his procedure. Meredith worries about DeLuca operating alone with Richard.

As the city of Seattle revels at the Phoenix Fair celebrating the city’s rebirth post-COVID, the Grey Sloan doctors treat a patient who encounters illegal fireworks. Meanwhile, Bailey has her sights set on hiring new doctors, but she’s having trouble finding viable options. Owen and Teddy attempt to take the next step in their engagement, and Meredith has a surprising opportunity when she meets a dynamic doctor from her mother‘s past.

The crossover starts on Station 19 S05E01 Phoenix from the Flame (I).

Meredith seeks advice from Amelia. Meanwhile, Richard is reenergized as he takes teaching to a new level at the hospital, and Winston treats a patient suffering from kidney failure.

Richard recruits Meredith and Bailey to help him launch a new program. Meanwhile, Addison’s patient has complications from a procedure, and Jo helps a woman who goes into premature labor.

The Grey Sloan doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. Owen experiences PTSD after he hears the explosion, while his sister Megan enlists help from Winston and Hayes in confidence. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.

The crossover starts on Station 19 S05E05 Things We Lost in the Fire (I).

It's Thanksgiving, and while Meredith faces travel complications due to the weather, Nick steps in to help in more ways than one; Richard and Bailey seek out emergency surgeries; Amelia and Link reconnect.

The doctors celebrate the holidays; Hamilton and Meredith prepare for a milestone on their project; Link wants to spend the holiday with Amelia and Scout as a family; Schmitt is faced with a difficult decision during surgery.

The Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own; Meredith works to save Dr. Hamilton's life. Levi is impacted from his latest loss.

Schmitt must face the Morbidity and Mortality conference. Meanwhile, Meredith convinces Nick to scrub in on a surgery in Seattle, and Jo faces her feelings.

While Richard ponders his surgical abilities, Jo is charmed by her patient’s brother. Elsewhere, Megan makes sure Teddy and Owen talk out their differences, and a pet python causes an uproar.