După primirea unor veşti neliniştitoare, Meredith şi Derek iau măsuri de prevenţie pentru viitorul copilului lor. Un grup de doctori sirieni soseşte la Spitalul Grey Sloan Memoria.

Spitalul e năpădit de pacienţi bolnavi de gripă, contaminându-i unul câte unul şi pe doctori. Derek se pregăteşte să ţină un discurs pe tema cartografierii creierului.

Secrete din trecutul lui Ellis Grey ies la iveală când Meredith urmăreşte nişte înregistrări vechi şi citeşte din jurnalul mamei sale. Între timp, Maggie îi surprinde pe toţii angajaţii spitalului cu un anunţ neaşteptat, iar Alex primeşte noi responsabilităţi.

Owen vine cu ideea ca stagiarii să înveţe o lecţie vitală despre anunţarea veştilor proaste rudelor pacienţilor, iar pacientul de 90 de ani al Arizonei o reasigură că e menită să găsească dragostea din nou.

Jackson află despre sarcina lui April, iar Alex şi echipa de doctori efectuează un complicat triplu-transplant. Meredith se gândeşte să aibă din nou relaţii amoroase, iar Andrew insistă să nu primească tratament special după ce el şi Maggie îşi oficializează relaţia.

A familiar face returns to Grey Sloan, throwing many of the doctors for a loop. With Catherine putting on the pressure, Bailey has to make a decision about Alex while a tough ER case makes Amelia’s bad day even worse.

Richard, Jackson, April and Catherine tackle a grueling trauma case intensified by hospital politics. Amelia finally faces her feelings about Owen, and Meredith gets caught between Nathan and Alex over a patient.

The stress of managing the hospital and coming to terms with Ben’s decision to become a Seattle firefighter pushes Bailey to her limits.

Maggie and Jackson are enjoying spending time together, but he must turn his concentration toward the groundbreaking vaginoplasty surgery he has scheduled with Catherine and Richard. Meanwhile, Meredith and Jo hit a roadblock with their contest submission, so Jo helps Bailey with an incoming trauma patient who used to be an astronaut

Meredith has a patient whose family is celebrating Day of the Dead, making the doctors remember loved ones they have lost. Richard shares unexpected news with Meredith about her father, Thatcher. Meanwhile, Teddy tries to tell Owen that she is pregnant but they get sidetracked, and Jo encourages Link to pursue one of the doctors.

Catherine is in Los Angeles getting the new foundation ready and summons Meredith and Koracick to visit for a highly confidential consult. Meanwhile, one of the nurses is 28 weeks pregnant and collapses at the hospital while talking to Richard.

Jackson creates an uncomfortable situation when he invites new girlfriend, Vic, to what he thinks is Richard and Catherine’s anniversary celebration, only to discover the dinner was called for different reasons. Elsewhere, Levi brings Nico on a trip to visit an ailing family member.

“Grey’s Anatomy” picks up where the previous episode of “Station 19” left off as both teams tend to a tense situation with so much at stake. Meanwhile, Jo convinces Hayes to bend the rules on a case, and Maggie and Winston reconnect.