The doctors of Seattle Grace are faced with the aftermath of last season's plane crash. As they try to move on with their lives, they must learn to adapt to the changes, cope with their losses and move forward with their relationships and careers.

The survivors from the crash are asked to make an almost impossible decision that will affect the rest of their lives. Meanwhile, tension grows between Jackson and April after they're forced to work together, and Alex tries to restrain himself with one of the interns.

Aware that Derek might never operate again, Meredith stops talking about the surgeries she's performing. Meanwhile, Richard calls on Dr. Catherine Avery to help him perform a complicated procedure, as things continue to heat up between Jackson and April; and Arizona's struggle to accept her fate forces Callie and Alex to face their guilt.

In this Meredith & Cristina-centric episode, the two friends continue to cope with life after the plane crash and their ever-growing responsibilities at their respective hospitals. As Meredith juggles taking care of Zola with a case that hits close to home, Cristina assists Dr. Thomas on a challenging heart surgery.

As the doctors continue with their lawsuit, they’re forced to confront the realities of their injuries. Meanwhile, Bailey tricks Arizona into helping her with a pediatric case, and Cristina tries to find normalcy in her new environment.

Cristina and Owen continue to figure out their relationship amidst the pending lawsuit; and Bailey argues with Ben over plans for their upcoming nuptials. Meanwhile, Callie recruits Jackson to help find a solution to Derek's hand, but he is preoccupied by a shocking situation with April.

The new batch of interns find themselves involved in all the drama at Seattle Grace: Meredith asks Heather to go above and beyond to help fix Derek's hand; Cristina starts a healthy competition between Stephanie and Leah, which inadvertently leads to a medical emergency for Cristina's patient; Alex sees Jo in a new light as they work to save a baby's life, and April teaches Shane a valuable lesson during "lumps and bumps" duty.

As the rest of the doctors prepare for Bailey's wedding, Richard helps her through a bout of pre-wedding jitters. Meanwhile, Lizzie butts heads with Meredith, and Callie and Jackson try to convince Derek to participate in a risky surgery that could fix his hand.

Bailey puts her wedding day on hold and continues her efforts to save Adele's life, Cristina and Owen remain undecided about their pending divorce, while Arizona and Callie try to get their spark back. Meanwhile, the hospital becomes inundated with a group of bikers after a horrible accident.

Meredith, Derek, Cristina and Arizona receive big news regarding the plane crash lawsuit, Richard avoids Catherine's romantic advances and Jackson takes on one of Mark Sloan's old patients. Meanwhile, Derek begins recovery on his hand.

The Seattle Grace doctors are on edge when a new medical professional enters the hospital; Arizona struggles with the emotional and physical pain of a phantom limb; and while battling pregnancy hormones, an overly-emotional Meredith is confronted with her worst fear.

As Derek and April work around the clock to find a solution for the hospital, Cristina struggles to respect the wishes of a family whose son is dying. Meanwhile, Arizona empathizes with a teenager who faces problems similar to her own.

Competition heats up as several of the doctors fight to become the new face of Seattle Grace; April brings in an emergency case, and Jackson and Alex work with a transgender teen couple. Meanwhile, the hospital implements new policies which test the patience of the staff.

As the hospital spirals closer to financial ruin, Owen must make some tough decisions, which includes foregoing an expensive surgery that could save the life of a child. Meanwhile, Alex and Jo work together to save the life of an infant, and April asks Jackson for dating advice.

As word of Seattle Grace's financial trouble spreads, Catherine encourages Jackson to move to Boston, and the interns fear they might lose their jobs. Meanwhile, the doctors meet with a potential investor in a last-ditch effort to save the hospital, and Alex impresses Jo while caring for a patient.

The discord and chaos created by the hospital's new management team causes one physician to question his future at Seattle Grace. Meanwhile, the doctors and the interns must juggle several transplant surgeries at once, each coming with its own set of obstacles.

A gas tanker explodes on a Seattle highway, causing multiple injuries, including paramedic Matthew. Meredith and Jo help a frantic mother whose child is suffering from a mysterious illness. Owen bonds with a young boy whose parents are in critical condition. Meanwhile true colors are revealed when Alex is forced to work with Jo's boyfriend on an ailing patient.

Upon receiving some unsettling news, Meredith and Derek take preventative steps for their children’s future; a group of Syrian doctors arrive at Grey Sloan Memorial Hospital for a crash course in basic surgical skills that they plan to apply in the field; and April decides to come clean to Matthew regarding the truth about her virginity. Meanwhile, multiple pre-op patients develop infections, causing one doctor to wonder if she is at fault.

The doctors reach out to Bailey but she continues to shut everyone out; after an incident with Ethan's grandmother, Owen fears the child could end up in foster care. A new craniofacial specialist arrives at Grey Sloan Memorial Hospital to work on a young patient. Meanwhile, a magician's assistant is rushed into the ER after a magic trick goes terribly wrong.

The doctors of Grey Sloan Memorial Hospital prepare for a super storm heading towards Seattle. Owen's desire to be a parent gets stronger as he becomes closer to Ethan. One wrong move puts the lives of Meredith and her baby in jeopardy. Meanwhile, Jo looks to Alex for help in a moment of crisis, and one doctor gets the shock of her life.

Grey Sloan Memorial Hospital enters crisis mode as the storm rages, resources become scarce and patients flood in by the busload. Meanwhile, one of the doctors fights for their life.

The Grey Sloan Memorial Hospital doctors are faced with the devastation left by the storm. A giant mudslide in Seattle injures a group of first responders and citizens, causing the already short handed ER to spring into action. Meanwhile, Meredith is faced with a tough decision that will affect the life of a loved one, Callie is rocked by the reality of Arizona’s infidelity, and Richard’s life is in extreme danger.

Callie makes a decision about her relationship; the doctors receive devastating news.

Derek and Meredith adjust to life at home with their newborn; Arizona tries to repair her marriage; Jackson and Owen clash over financial issues.

The doctors of Grey Sloan Memorial throw a fundraising gala which turns wildly competitive after Jackson makes a rash promise. Back at the hospital, Bailey’s patience is tested when she has to deal with several extremely difficult patients. Meanwhile, Shane and Stephanie handle an incredibly busy ER by themselves and Alex reveals an emotional secret to Jo.

Meredith struggles to balance her roles as a surgeon and a mother when she returns to work; Stephanie tries to impress Jackson's mother; Jo becomes overly involved with a patient.

Derek and Callie work on a brain mapping project, Richard encourages the interns to use his physical condition as a learning tool and after a discussion with Callie, Meredith considers continuing her mother’s research. Meanwhile, Shane continues to feel guilty about Heather’s death.

Costumed patients create a challenge for the doctors; Derek and Ben work on a new surgical technique; Richard asks a resident to perform his next surgery, angering Bailey.

A betrayal intensifies the issues between Cristina and Meredith; Matthew and April make a decision about their relationship; Bailey faces difficulties with Ben's return.

When an unexpected malpractice suit turns Callie's world upside down, her supportive father arrives and shares an interesting secret with her. Meanwhile, through flashbacks, we learn some surprising details about Callie and Arizona's marriage.

Ben worries that a casual conversation with Derek could potentially cause issues for Bailey, Cristina turns to Shane as tension grows with Meredith, and April's upcoming wedding makes for an uncomfortable situation between Jackson and Stephanie. Meanwhile, Meredith plans a Thanksgiving dinner at her house.

April’s sisters arrive to help celebrate April’s upcoming nuptials and quickly get on her nerves. Matthew and Jackson are forced to work together when they witness a terrible accident, Callie and Arizona work hard to reestablish their relationship and Cristina is pressured to live stream an upcoming surgery. Meanwhile, a familiar face returns to the hospital.

On the day of April's wedding, the Grey Sloan Memorial doctors are all preoccupied with their own drama. Meredith and Cristina continue to argue about their research and careers, Bailey comes clean to Ben about her feelings regarding him moving back to Seattle, and Shane puts himself in a risky situation. Meanwhile, Derek gets a phone call that will change his life.

The doctors are faced with the consequences of the events at April's wedding. Alex reacts to the news about his father. Callie and Arizona make a decision about their relationship.

After an anonymous complaint is issued by one of their own, the hospital implements a non-fraternizing policy causing the couples to panic. Meanwhile, Emma and Owen talk about the future, Cristina and Meredith enjoy a little girl time, and Richard enlists the residents to help research a rare cancer case.

Arizona has a bad day which escalates when she advises one of Callie's patients on a potential double amputation. Derek goes back on a promise to Callie, and Jo and Stephanie come across an abandoned baby outside the hospital. Meanwhile, the doctors deal with the repercussions of the non-fraternization rule, which include meetings with HR and one doctor's suspension.

It's Richard's birthday and Bailey invites him to scrub in on the case of a lifetime. Meredith hires a research assistant to help with her portal vein project. A scorned Callie gives Derek quite the shock. Meanwhile, Shane helps screen candidates for Cristina's clinical trial and meets a young expectant mother who needs his help.

Cristina imagines the two routes her life can take based on one decision she makes. Meanwhile one of the hospital’s patients decides whether or not to live.

The hospital gets inundated with flu infected patients, which causes the doctors to slowly fall ill one by one. Derek must fight off the sickness as he prepares to give a speech on brain mapping and the residents place bets on who will fall ill first. Meanwhile, a new doctor at the hospital gives Alex a glimpse into an alternate form of medical practice.

Cristina won't let herself get excited when she is nominated for a Harper Avery award; Alex thinks about making a change; Callie and Derek work with a machine that recognizes emotions.

Cristina enlists Meredith to help her prepare an acceptance speech for her possible Harper Avery win and while Owen offers to attend the ceremony with her, she insists on going alone. Meanwhile, Derek feels overwhelmed between his responsibilities at home and at the hospital. April and Jackson come to a disagreement on children and religion, and Callie and Arizona try to reconnect in their marriage.

Jackson is given the daunting task of delivering disappointing news to the doctors. Meanwhile, Derek's sister Amelia drops by for a surprise visit, Richard surprises Catherine in Boston and when Bailey gets frustrated by the slow pace of her research, she makes a risky decision.

Cristina considers her future at the hospital; Amelia and Derek collaborate on a tough surgery involving conjoined twins; Jo takes on too many cases at once; Stephanie stumbles on the truth about Bailey's case.

With Derek away, Meredith spends time with Amelia and finds out her true feelings about her time in Seattle. Bailey deals with the ramifications of her actions and Callie receives devastating news. Meanwhile, the residents panic after hearing that one of them will be fired

The doctors of Grey Sloan Memorial Hospital bid an emotional farewell to the beloved Cristina Yang. A possible act of terrorism rocks Seattle and causes chaos at the hospital. Meanwhile, Meredith makes a life changing decision and one doctor receives shocking news.

With Cristina gone, a new doctor, Maggie Pierce, making the rounds and Derek wanting to move to Washington DC, Meredith struggles to regain a sense of normalcy both at home and in the hospital. Meanwhile, Callie and Arizona come to a decision about surrogacy, Amelia overhears a big secret, Bailey realizes she will have to fight Alex for Cristina’s board seat and a freak accident causes two teenagers to be caught in a very compromising position.

Maggie tries to make a good impression but finds herself in unfortunate situations; Richard keeps hiding his secret.

Owen tries to get Callie to help Veterans Hospital patients with the robotic limb lab. Alex and Meredith's friendship makes Jo jealous. Alex and Bailey prepare to go in front of the board.

Secrets from Ellis Grey’s past come to light when Meredith watches old videos and reads through her mother’s journals. Meanwhile, Maggie rocks the hospital with an unexpected announcement; Alex gets new responsibilities and Callie focuses her attention on the Veterans’ project.

Callie and Arizona examine their marital problems and what's contributed to them. Meanwhile, Callie devotes herself to the veterans' project, Arizona strives to impress Dr. Herman, and Richard seeks guidance from Bailey.

Owen becomes invested in a patient when he realizes she may have served in the military, April’s mother pays her daughter a visit and bonds with Jackson, and Derek plans a family dinner. Meanwhile, a patient’s diagnosis causes Bailey to reconsider her own health issues and Dr. Herman drops a bombshell on Arizona

Information about Amelia's past emerges and causes problems for her at the hospital.

Maggie and Meredith disagree with Derek about the best way to approach a patient’s case, which leads to a bigger argument between the couple. Meanwhile Callie feels responsible when one of her veterans is pushed too far and one doctor’s routine procedure results in a devastating diagnosis.

As Derek prepares for his move to DC, Meredith keeps herself busy at the hospital. Meanwhile, Jackson and April deal with difficult news, and Arizona and Amelia discuss how to best approach Dr. Herman.

April stays optimistic as Arizona begins testing on her baby; Dr. Herman plans out a crash course in fetal surgery; and Owen and Callie encourage each other to get back into the dating scene. Meanwhile, Meredith, Maggie and Bailey use the 3D printer to gain a better understanding of their patient's tumor.

After several discussions with Dr. Herman, April and Jackson must face their situation head on and make a difficult decision regarding their unborn child. Catherine arrives in Seattle and bumps into Richard at the hospital. Meanwhile, Meredith tries to find someone to take care of the kids so she can visit Derek for the weekend, and Amelia shows Stephanie some tough love when they work together on a case

Maggie gets upset when Meredith dodges her questions about DC; Bailey and Ben become concerned about Ben’s brother after he is admitted to the hospital, and Dr. Herman starts to warm up to Arizona. Meanwhile, Richard feels manipulated by Catherine.

The hospital doctors become fascinated with Dr. Herman’s case when Amelia gives a lecture detailing the intricacies of the surgery. Arizona and Herman continue to bond over the amount of cases they are trying to complete before the big surgery. Meanwhile, Bailey brings them a case of a pregnant woman who is close to her heart.

In this Amelia-centric episode, Amelia engages in the surgery of a lifetime as a crowd of doctors look on from the gallery. With Stephanie by her side, she begins operating on Dr. Herman, but quickly realizes it's far more difficult than she anticipated. Meanwhile, Bailey becomes skeptical when Arizona takes on one of Herman’s cases.

An earthquake shakes the ground at Grey Sloan Memorial Hospital, trapping Maggie in an elevator and threatening Meredith’s long streak of successful surgeries. Meanwhile, Owen gives medical advice to a child over the phone and Ben confides in Jackson.

A patient's condition sparks a conversation between Richard and Maggie about Alzheimer's disease; April and Jackson struggle to return to their normal lives and Arizona is faced with the reality that Callie is moving on. Meanwhile, Meredith reveals her biggest fears about Derek.

Meredith, rattled by the latest events, tries to figure out what to do about Derek. Meanwhile, Owen is shocked when his mother is admitted to the hospital.

A school field trip to the hospital takes a dramatic turn when the kids witness two injured cops enter the emergency room. Meanwhile, Stephanie sets her eyes on one of the chaperons, Callie operates on the leg of the police captain and Amelia must face her feelings for Owen.

Upon realizing that Owen and Amelia have been seeing each other behind her back, Meredith comes down hard on her sister-in-law causing Amelia to rethink things. Meanwhile, Catherine springs into action when a man is brought into the hospital after his wife seeks revenge on his cheating ways.

A small plane crash in Seattle causes multiple casualties and brings back horrible memories for the doctors, especially Meredith and Arizona. Meanwhile, friction between Owen and Amelia makes for an uncomfortable working situation for Stephanie.

Derek witnesses a horrible car accident and springs into action to save lives.

Meredith and the staff feel the impact of losing one of their own; Jackson struggles with April's decision; Bailey and Ben argue about their future. Months after Derek's funeral, Amelia struggles with her emotions; April plans to return; and Derek's part in Meredith's life continues to grow.

The doctors of Grey Sloan Memorial Hospital are forced to put their emotions aside when a catastrophic event occurs.

As the doctors continue to tackle an unfathomable crisis, they are reminded of what is important and are brought closer together.

The doctors from Grey Sloan Memorial Hospital spring into action to save the lives of two girls with a powerful story. Meanwhile, Meredith tries to cope with the fact that Amelia is now living with her and Jackson prepares for April's return back to Seattle.

The pressure is on as a determined Bailey tackles her first day as Chief; meanwhile, April's marriage is in jeopardy and she finds herself unable to address her problems; Meredith struggles to juggle all her responsibilities and Amelia works to define her relationship with Owen.

Maggie reevaluates her life choices after receiving an invitation to her ex-boyfriend’s wedding; Richard questions Bailey’s loyalty, and Jo confides in Stephanie about a secret she’s been keeping from Alex. Meanwhile, Alex struggles with making a difficult decision that will affect the lives of newborn twins.

Owen suggests the interns learn a vital lesson on how to break bad news to patients’ families, and Arizona’s 90-year-old patient reassures her that she’s destined to find love again. Meanwhile, the sisters completely forget about the dinner party they’re hosting for everyone.

In the midst of the sisters’ dinner party, Maggie ditches her cooking duties to rush to the hospital. Meanwhile, April steps in to help cook as an attempt to avoid Jackson, and Arizona nervously waits to find out more about Callie’s new girlfriend.

Grey Sloan Memorial not only welcomes a new transfer resident, but also a patient who's the topic of converstation after accidentally sending his sex tape to his entire congregation. Meanwhile, Richard wrestles with how to progress his relationship with Maggie when an old friend visits the hospital, and April brings in a case of a young boy from the Middle-East.

The team of doctors work on a high stakes case of a long time patient, adding additional pressure to an already tense environment. Meanwhile, Bailey wants Ben to kick out their new roommate, and Arizona is eager to get back into the dating world with a new wingman.

Midseason Finale - As the rumor mill around the hospital continues to spiral out of control, Grey Sloan Memorial is flooded with injured firefighters from a nearby wildfire. Maggie struggles to keep things with Andrew professional at work; meanwhile, Jo questions Alex’s priorities.

Meredith is brutally attacked by a patient, and Penny is the one who discovers her. The doctors of Grey Sloan Memorial rush to stabilize Meredith and remain by her side in the harrowing aftermath.

Everybody attempts to deals with Meredith's trauma as Maggie and Callie perform a risky, experimental surgery on a teenager. Nathan and Owen continue to be at odds. Maggie and Andrew's relationship continues to progress.

The evolution of April and Jackson’s relationship is revealed through a series of flashbacks dating back to when they first met. Simultaneously, we follow the years-long progress of one of Jackson’s patients.

A patient from Meredith's very first surgery as an Intern is readmitted to Grey Sloan Memorial with a new aneurysm, and Amelia takes her case. Meanwhile, Maggie suspects that Richard knows about her relationship with Andrew, and Arizona debates dating again.

Meredith, Bailey, Jackson, Callie and Jo travel to a military hospital to perform an extraordinary and extremely risky surgery on a veteran with an advanced tumor. Meanwhile back at Grey Sloan, Andrew is tired of being Maggie’s worst kept secret; Ben makes an impulsive surgical decision; and a team of cheerleaders wreak havoc in the ER.

There is plenty of turmoil after Richard messes with the staff pairings. Arizona takes a risk to help a woman who is pregnant with quadruplets.

Jackson learns about April's pregnancy, while Alex and the team of doctors handle an hours-long triple-organ transplant surgery. Meredith considers dating again, and Andrew insists on not receiving special treatment after he and Maggie go public.

Meredith takes a step forward with Will but quickly regrets it; Maggie senses a disconnection with Andrew; and Amelia reevaluates her relationship with Owen. Meanwhile, Catherine comes into town and really shakes things up with April and Jackson.

Meredith goes on an ambulance ride with Owen and Nathan to pick up a heart for a transplant patient. Musician & MS patient Kyle Diaz is admitted to Grey Sloan Memorial with a tremor in his hand, and the residents apply for the Preminger Grant. Meanwhile, Catherine continues to insert herself into Jackson and April’s business against Richard’s wishes.

After a missing child forces the hospital into lockdown, Ben decides to operate on a pregnant mother without the proper surgical equipment. Miranda, as Chief, is faced with the repercussions of the event and whether or not Ben's impulsive actions were justified.

Miranda continues to deal with the aftermath of Ben's reckless decision and forms an advisory committee to recommend proper disciplinary action against him. Meanwhile, April and Jackson try to put their differences aside for the sake of their baby, and Arizona makes a decision that could affect her relationship with Callie forever.

The doctors work frantically to save a young boy who was accidentally shot. Meanwhile, Arizona is upset when Callie tries to make an important decision about Sofia’s future without consulting her

Stephanie’s relationship with Kyle becomes complicated. Meanwhile, Meredith encourages Amelia and Owen to take a chance and choose to be a real couple. Arizona and Callie are at odds and put their friends in the middle of an uncomfortable situation.

Callie and Arizona are at odds over Sofia’s future, and Stephanie questions the status of her relationship with Kyle. Meanwhile, Alex and April work on a pregnant teen that is readmitted to Grey Sloan Memorial.

Owen and Amelia take their relationship to the next level; Alex gains some clarity on his future with Jo; and Callie and Arizona continue to struggle with the current custody arrangement.

Meredith and Maggie support Amelia on an important day; Jo reveals that she has been keeping secrets from Alex while Arizona and Callie deal with the impact of their custody arrangement. Meanwhile, Ben leaps into action to help a friend.

When one of Grey Sloan’s own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help. Meredith juggles huge secrets that affect her relationships with Alex and Maggie. While Richard helps Jo with a big decision, April and Catherine clash over the new baby.

Meredith considers her loyalties, as Alex deals with the repercussions of his actions. Newlyweds Amelia and Owen host a dinner party with unlikely guests, and Jackson proposes an arrangement to help April through her recovery.

A car crash at a funeral brings a bickering family into the hospital. Back from New York, Arizona ends up caught between Alex and Andrew. While Ben takes on a new parenting role, Amelia helps Meredith and Maggie through a problem.

Alex tries to do the right thing but still cant catch a break. Jackson and April adjust to their “new normal” with the baby. While Meredith and Nathan establish what’s going on between them, Amelia questions the state of her relationship with Owen.

Meredith and Bailey are at odds when both of their patients need a liver transplant, Owen seeks help from the other doctors when he is charged with babysitting baby Harriet for the day, and Amelia struggles with telling Owen some important news.

A familiar face returns to Grey Sloan, throwing many of the doctors for a loop. With Catherine putting on the pressure, Bailey has to make a decision about Alex while a tough ER case makes Amelia’s bad day even worse.

The arrival of a new consultant puts all of the doctors on edge, especially once she starts stepping on toes in the OR. Amelia and Owen bring their personal problems into the hospital, while April explores some uncharted territory.

A difficult surgery brings back pivotal memories for Meredith, Richard, Owen and Stephanie, as they work together to save a life.

Believing he is going to jail tomorrow, Alex makes a big decision about his future. While the hospital is overrun with victims of a building collapse, Richard demands answers from Bailey about Eliza’s presence at Grey Sloan.

Bailey, Arizona and Jo go to a maximum security women’s prison to treat a violent, 16-year-old pregnant girl and her unborn baby.

Richard and the attendings set out to make Eliza’s first day at Grey Sloan a bumpy one. Meanwhile, Meredith tries to track down Alex.

Maggie gets a surprise visit from her mother at the hospital. Bailey has to make a difficult decision when one of the attendings refuses to work with Eliza, and Stephanie gets caught up in Owen and Amelia’s personal drama.

The residents are excited for Eliza’s next phase of teaching, but they spend the day caught between the warring attendings. Meanwhile, April has a challenging first day in her new role at the hospital.

Alex returns to the hospital and discovers a lot has changed since he left. Meanwhile, Jo has to make a difficult decision on a case, and Arizona tries to distance herself from Eliza.

Richard, Jackson, April and Catherine tackle a grueling trauma case intensified by hospital politics. Amelia finally faces her feelings about Owen, and Meredith gets caught between Nathan and Alex over a patient.

Jackson and April travel to Montana in order to perform a complicated surgery on a young patient, but Jackson’s mind is elsewhere, and April is forced to step up and get him back on track.

Diane Pierce returns to Grey Sloan, but Maggie is still in the dark as to why she’s really there. Owen and Amelia hash out their problems as they work a trauma case together, and Bailey tries to mend her relationship with Richard.

When Maggie’s mom’s health deteriorates, the doctors are at odds over how to treat her. Meanwhile, Richard comes to grips with Bailey’s betrayal over the Residency Program.

When Maggie takes on a big case, many of the doctors are worried she’s not the right one for the job while Stephanie makes a mistake treating one of Grey Sloan’s own.

Meredith and Nathan have to confront their feelings when they are are stuck sitting next to each other on a plane.

Bailey and April work to fix things between Richard and Catherine; Eliza continues to pursue Arizona; one of Alex's previous patients returns to Grey Sloan.

April and Andrew consult with a fiery patient who has a giant, inoperable heart tumor. Meanwhile, Alex and Eliza are at odds over the treatment of a young patient, and Stephanie and Ben make decisions that could affect their careers.

The doctors of Grey Sloan encounter a difficult case involving a dangerous patient. Meanwhile, Owen receives life-changing news that pushes Amelia to step up to support him, and Alex attends a medical conference after making a shocking discovery.

The doctors’ lives are at risk after a dangerous patient escapes the hospital room. Alex must make a hard choice in his relationship with Jo while Meredith has some big news for Nathan that brings things to a turning point.