When Holmes is implicated in the murder of a woman who was killed during the height of his addiction, he investigates himself to find their connection. As Holmes retraces his steps with Watson’s help, the clues make his confidence in his own character waver.

Holmes and Watson take on an investigation of a personal nature when Holmes’ recovery sponsor, Alfredo, suddenly disappears. As they delve into Alfredo’s life for clues, Holmes questions whether their friend has been abducted, or worse, if he suffered a relapse into addiction.