Holmes and Watson follow a blood trail into the world of wrongful death compensation when they investigate a series of murders in which the killer leaves envelopes of cash on the victims. Also, Holmes makes a generous gesture towards Watson as she suffers through the aftermath of a personal crisis.

Holmes and Watson investigate a murder that initially looks like a road rage incident, but takes a new direction when they learn the victim was flash-frozen at the time of death. Also, when Watson’s mother finds out Joan’s brother is cheating on his wife, she puts Joan in the awkward position of confronting him about the affair.

When a driver for a ridesharing company is intentionally run over by a city cab, Holmes and Watson wonder if it’s a case of professional jealousy. A casual romance Holmes has with one of his longtime "Irregular" consultants becomes complicated when the woman makes a shocking request.

Holmes and Watson find themselves in the middle of a civil war being fought on the Internet when a member of Everyone, the anonymous hacker group they periodically work with, is murdered.

Holmes and Watson investigate the murder of a professional skeptic, a man who debunked paranormal, religious and scientific phenomenon for a living. The case becomes urgent when his homicide reveals a potential threat to homeland security. Also, Captain Gregson’s daughter and fellow NYPD officer, Hannah, asks Watson for help with one of her cases.

Joan worries Sherlock’s sobriety is at risk when she learns he has been lying to her about attending recovery meetings. Also, Sherlock and Joan discover a man’s death caused by ingesting poisoned sausage is connected to a lab working on a breakthrough in the artificial meat industry.

When Holmes and Watson investigate a clown’s murder upstate, they discover a connection between his death and the creation of a new weaponized virus. Also, Watson helps Bell when he’s targeted by his new love interest Chantal’s ex-husband in attempt to sabotage her career at the district attorney’s office.

Holmes and Watson investigate the murder of a man Sherlock considered one of New York’s worst private investigators. Also, as Holmes stews over being beaten by Shinwell, he decides to take out his aggression by dismantling a local organization of private investigators.

Holmes and Watson get mixed up in murder and magic when they investigate the death of a magician killed while performing a classic stunt. Also, Watson suspects Bell is being targeted by the ex-husband of his girlfriend, Chantal, after a false allegation lands him the middle of an Internal Affairs investigation.