Когато главатарят на местна улична банда отвлича Холмс, за да го принуди да открие кой е нападнал бандата му, Холмс и Уотсън се озовават в центъра на международно издирване на стар и безценен артефакт.

Season 5 ends with Holmes and Watson pursuing an elusive criminal as a gang war erupts in New York City. While the NYPD works to contain the violence, the two investigate the murder that appears to have ignited the city-wide conflict and discover that a familiar face is pulling the strings.

After an explosion at a traffic stop, Holmes and Watson must determine whether the attack was a terrorist attack; Holmes and Watson suspect there is more for them to discover regarding the recent attack on someone within their inner circle.