Sherlock assists with a double homicide that has the same M.O. as a series of murders that took place 13 years ago. Meanwhile, after being frozen out by Sherlock, Watson visits his old rehab center in order to learn more about the mysterious man in her care.

Sherlock investigates a case involving a wealthy philanthropist who believes his incurable illness was given to him on purpose. Meanwhile, Sherlock tries to teach Joan his deductive skills by sending her to a suspicious dry cleaning establishment.

As Sherlock reels at the reappearance of his former lover, Irene Adler, a series of flashbacks unravel the tumultuous events that led to his downfall into addiction. Meanwhile, he and Joan once again find themselves in the crosshairs of the enigmatic Moriarty.

Holmes and Watson consult on a case in which a man suspected of murdering his wife years ago receives a ransom demand for her safe return. Meanwhile, Lestrade overstays his welcome at the brownstone and seems unwilling to leave.

When Sherlock’s brother Mycroft makes a surprise return to New York, his motivations cause discord between Sherlock and Joan. Meanwhile, a missing person case takes Sherlock and Joan inside the world of unmanned aeronautics.

As Kitty begins to unravel due to the imminent threat to her safety, Sherlock and Joan intensify their efforts to help her. Also, the origin of Sherlock and Kitty’s relationship is revealed.

When a driver for a ridesharing company is intentionally run over by a city cab, Holmes and Watson wonder if it’s a case of professional jealousy. A casual romance Holmes has with one of his longtime "Irregular" consultants becomes complicated when the woman makes a shocking request.

After a vigilante dressed up as a comic book hero is murdered, Holmes and Watson need to find the man's true identity and find his killer.

Holmes and Watson find themselves on the hunt for a serial killer after a murder rocks their inner circle. Also, Holmes’ neurological recovery regresses and his sobriety wavers as his commitment to catching the killer grows into an obsession.