Thieves hijack medical supplies sent to Glades Memorial. Oliver gets into a heated battle with China White and her new partner, the Bronze Tiger, over the supplies. Meanwhile, Laurel makes plans to catch the Arrow; and Thea give Roy an ultimatum.

Oliver discovers a man who goes by the name “The Mayor” is bringing illegal guns in to The Glades, so Oliver sponsors a “Cash for Guns” event to help clean up the city. Unfortunately, The Mayor crashes the event with his gang and seriously injures Sin. The Canary is furious when she learns her friend is in the hospital and sets out for revenge. Meanwhile, Felicity stuns Oliver with a bit of information about the Canary, Donner asks Laurel to dinner, and Diggle reconnects with an old friend.

The Count has a new scheme to turn Starling City's residents into clients by addicting them to a new drug and then selling them Vertigo to cure it. among those stricken are Diggle and DA Donner, who collapses in the middle of presenting his case against Moira.

When a superhumanly strong thief robs a Queen Consolidated warehouse, Central City police scientist Barry Allen comes to Starling City to investigate the case. However, despite his close working relationship with Felicity, Oliver suspects that there's more to the young scientist than meets the eye. Meanwhile, Sin asks Roy to help investigate the disappearance of a friend. In the past, Oliver, Shado, and Sara try to get Slade to the submarine so they can use the serum to save his life.

After covering from a near-fatal drug overdose, Oliver begins hallucinating people from his past. Believing he's a liability, Oliver gives the information he has on Cyrus Gold to Quentin... which results in the deaths of several police officers. Meanwhile, Brother Blood captures Roy and uses him as a test subject for his new serum. In the past on the island, Ivo gives Oliver an impossible choice to make.

A bomber nicknamed Shrapnel has set his sights on Sebastian Blood, and Oliver dons his mask to protect his newfound ally. Meanwhile, Laurel investigates Sebastian's aunt who is locked up in a mental institution, and Thea learns about Roy's newfound superstrength.

When her father won't believe her accusations against Sebastian, Laurel turns to the Arrow for help. Oliver has his own doubts about Laurel, particularly when she is arrested on a charge of drug possession. Meanwhile, Roy sets out to test his new abilities but goes berserk, putting a man in the hospital.

As Laurel continues to unravel, Oliver and Lance try to convince Sara to stay in Starling City and finally reunite with Laurel and Dinah. However, Sara’s fellow League of Assassins member, Nyssa, comes to bring Sara back to the fold, but when Sara refuses, Nyssa kidnaps Dinah. Realizing she’s putting her family in danger by staying in town, Sara considers re-joining the league.

Sara and Roy become prisoners at the Slade and the only one who is able to save them is Oliver Queen.

The Mirakuru sends Roy into an uncontrollable rage and he unleashes on the city. Oliver realizes the Mirakuru has taken over Roy completely and must figure out a way to stop him.

After the death of someone close to him, Oliver decides to give himself up to Slade rather than risk further bloodshed on his friends and family. Meanwhile, Laurel renews her investigation into Sebastian Blood, and Slade makes his final plans to unleash his Mirakuru-enhanced army on Starling City.

Oliver rallies his team as Slade's soldiers attack the city. Felicity gets a call from S.T.A.R. Labs with game-changing news and Thea comes face-to-face with her father.