Reese and Finch get some help from Detective Fusco as they surveil their latest POI, Dr. Megan Tillman, while she’s on call and after hours to unravel the threat surrounding the promising young physician.

Reese and Finch’s game of cat and mouse with Detective Carter becomes infinitely more complicated when The Machine declares that she is their newest POI.

Reese discovers there’s more to the story after he infiltrates a smuggling ring to get close to his latest POI.

With Finch missing – kidnapped by his hacker nemesis, Root, Reese enlists Detectives Carter and Fusco to get his friend back, Meanwhile, The Machine never sleeps, disseminating a new number to Reese.

Finch and Reese meet their match: a tech billionaire whose curiosity and endless resources could expose their identities and ruin their efforts to save his life.

The Machine, now completely self-governed with its whereabouts unknown, resumes giving Finch its "irrelevant" numbers for people in danger, which include a U.S. naval officer in town for Fleet Week. However, with so many sailors flooding the streets of New York City, finding the officer in time presents an even bigger challenge for Reese and Shaw.

The battle to bring a crime organization to justice reaches a new level; Reese's number comes up in the machine.

Reese and Shaw pose as alumni at a high school reunion in order to keep eyes on the latest POI. Meanwhile, Finch and Fusco travel to Washington, D.C., to investigate the motivations behind Vigilance’s latest attack.

Reese's cover job as a detective at the NYPD becomes complicated when the young brother and sister he's protecting become targets of a gang investigation.

Samaritan launches a cyber-attack on the stock exchange, forcing the team to risk their lives in a desperate mission to stop a global economic catastrophe.

Reese and Fusco get caught in the war between the two newest POIs, rival crime bosses Elias and Dominic. Also, a tantalizing clue to Shaw’s whereabouts leads Finch and Root into a possible trap, and Control goes rogue to uncover the true intentions of the Samaritan program.

Shaw escapes her captors, but the team is unsure of her mental state when she begins to act paranoid and reckless.

Finch, Reese, Fusco and Shaw embark on one last mission to prevent Samaritan from destroying The Machine and cementing its hold over mankind.